Phthalylsulfathiazole

Modify Date: 2024-01-02 20:43:10

Phthalylsulfathiazole Structure
Phthalylsulfathiazole structure
Common Name Phthalylsulfathiazole
CAS Number 85-73-4 Molecular Weight 403.432
Density 1.6±0.1 g/cm3 Boiling Point 579ºC at 760 mmHg
Molecular Formula C17H13N3O5S2 Melting Point 198-204°C
MSDS USA Flash Point 304ºC

 Use of Phthalylsulfathiazole


Phthalylsulfathiazole is a kind of sulfonamides used as an antibacterial drug.

 Names

Name Phthalylsulfathiazole
Synonym More Synonyms

 Phthalylsulfathiazole Biological Activity

Description Phthalylsulfathiazole is a kind of sulfonamides used as an antibacterial drug.
Related Catalog
References

[1]. S. RAGHAV, et al. Kinetics of Xylene Coagulation in Water Emulsion Stabilized by Phthalylsulfathiazole. ACS Symposium Series, 1985: 447-460

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 579ºC at 760 mmHg
Melting Point 198-204°C
Molecular Formula C17H13N3O5S2
Molecular Weight 403.432
Flash Point 304ºC
Exact Mass 403.029663
PSA 162.08000
LogP 1.54
Index of Refraction 1.715
Storage condition -20°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TH8575000
CHEMICAL NAME :
Phthalanilic acid, 4'-(2-thiazolylsulfamoyl)-
CAS REGISTRY NUMBER :
85-73-4
LAST UPDATED :
199701
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C17-H13-N3-O5-S2
MOLECULAR WEIGHT :
403.45
WISWESSER LINE NOTATION :
T5N CSJ BMSWR DMVR BVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 58(12),9,1993
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 81,116,1944
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
920 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 81,116,1944 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
12900 mg/kg/30D-I
TOXIC EFFECTS :
Gastrointestinal - changes in structure or function of esophagus
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 58(12),9,1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84641 No. of Facilities: 193 (estimated) No. of Industries: 2 No. of Occupations: 6 No. of Employees: 9471 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84641 No. of Facilities: 16 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 94 (estimated) No. of Female Employees: 62 (estimated)

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR 3249
RTECS TH8575000
Packaging Group III
Hazard Class 6.1(b)
HS Code 2935009090

 Synthetic Route

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Literature: Meditsinskaya Promyshlennost SSSR, , vol. 11, # 12 p. 17,20 Chem.Abstr., , p. 15505

 Customs

HS Code 2935009090
Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

 Articles25

More Articles
[Experimental basis for the tentative permissible levels of phthalazol, sulfadimethoxine and Bepask in bodies of water].

Gig. Sanit. (12) , 9-10, (1993)

Tentative permissible levels (TPL) of phthalazol, sulfadimethoxine, and Bepask in the water were substantiated on the basis of study of organoleptic properties, of influence on sanitary status of wate...

The effect of antibacterial agents on the intestinal flora of patients: the use of aureomycin, chloromycetin, dihydrostreptomycin, sulfasuxidine and sulfathalidine.

Gastroenterology 16(1) , 12-8, (1950)

The effects of phthalylsulphathiazole on the bacteria of the colonic mucosa and intestinal contents as revealed by the examination of surgical samples.

Scand. J. Gastroenterol. 14(7) , 891-6, (1979)

The isolation of a bacterial flora specifically associated with the colonic mucosa of patients undergoing large-bowel surgery is described. This flora differed from that of faeces in both the numbers ...

 Synonyms

Cremothalidine
Phthalylsulfathiazole
Taloudron
Ftalazol
2-[({4-[(1,3-thiazol-2-ylamino)sulfonyl]phenyl}amino)carbonyl]benzoic acid
N-(4-thiazol-2-ylsulfamoyl-phenyl)-phthalamic acid
Talidine
entexidin
Phtalazol
N-(4-Thiazol-2-ylsulfamoyl-phenyl)-phthalamidsaeure
EINECS 201-627-4
Benzoic acid, 2-[[[4-[(2-thiazolylamino)sulfonyl]phenyl]amino]carbonyl]-
Sulftalyl
PST
2-[({4-[(2-thiazolylamino)sulfonyl]phenyl}amino)carbonyl]-benzoic acid
Thalinil
Ftalysept
2-{[4-(1,3-Thiazol-2-ylsulfamoyl)phenyl]carbamoyl}benzoic acid
MFCD00005318
Taleudron
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