FPTQ

Modify Date: 2024-01-23 20:02:41

FPTQ structure	Common Name	FPTQ
	CAS Number	864863-72-9	Molecular Weight	305.309
	Density	1.4±0.1 g/cm3	Boiling Point	523.8±60.0 °C at 760 mmHg
	Molecular Formula	C₁₇H₁₂FN₅	Melting Point	N/A
	MSDS	N/A	Flash Point	270.6±32.9 °C

Use of FPTQ

FPTQ is mGluR1 antagonist with IC50 of 6 nM and 1.4 nM for human and mouse mGluR1 respectively. Inhibit [3H] FTIDC target: mGluR1IC 50: 6 nM [1]In vivo: FPTQ exhibited dose-dependent and plasma concentration-dependent receptor occupancy in the cerebellum and striatum. Compound A inhibit (S)-3,5-DHPG-induced face-washing behavior by 46 ± 14% and 97 ± 6.6% (mean ± S.E.M., n = 6) at 10 and 30 mg/kg, respectively.[2]

Name	FPTQ
Synonym	More Synonyms

Description	FPTQ is mGluR1 antagonist with IC50 of 6 nM and 1.4 nM for human and mouse mGluR1 respectively. Inhibit [3H] FTIDC target: mGluR1IC 50: 6 nM [1]In vivo: FPTQ exhibited dose-dependent and plasma concentration-dependent receptor occupancy in the cerebellum and striatum. Compound A inhibit (S)-3,5-DHPG-induced face-washing behavior by 46 ± 14% and 97 ± 6.6% (mean ± S.E.M., n = 6) at 10 and 30 mg/kg, respectively.[2]
Related Catalog	Research Areas >> Others
References	[1]. Fujinaga M et al. Synthesis and evaluation of 6-[1-(2-[(18)F]fluoro-3-pyridyl)-5-methyl-1H-1,2,3-triazol-4-yl]quinoline for positron emission tomography imaging of the metabotropic glutamate receptor type 1 in brain. Bioorg Med Chem, 2011 Jan 1, 19(1):102 [2]. Suzuki G et al. Correlation of receptor occupancy of metabotropic glutamate receptor subtype 1 (mGluR1) in mouse brain with in vivo activity of allosteric mGluR1 antagonists. J Pharmacol Sci, 2009 Jul, 110(3):315-25.

Description

Related Catalog

Research Areas >> Others

References

[1]. Fujinaga M et al. Synthesis and evaluation of 6-[1-(2-[(18)F]fluoro-3-pyridyl)-5-methyl-1H-1,2,3-triazol-4-yl]quinoline for positron emission tomography imaging of the metabotropic glutamate receptor type 1 in brain. Bioorg Med Chem, 2011 Jan 1, 19(1):102

[2]. Suzuki G et al. Correlation of receptor occupancy of metabotropic glutamate receptor subtype 1 (mGluR1) in mouse brain with in vivo activity of allosteric mGluR1 antagonists. J Pharmacol Sci, 2009 Jul, 110(3):315-25.

Density	1.4±0.1 g/cm3
Boiling Point	523.8±60.0 °C at 760 mmHg
Molecular Formula	C₁₇H₁₂FN₅
Molecular Weight	305.309
Flash Point	270.6±32.9 °C
Exact Mass	305.107666
LogP	2.55
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.700

6-[1-(2-Fluoro-3-pyridinyl)-5-methyl-1H-1,2,3-triazol-4-yl]quinoline

Quinoline, 6-[1-(2-fluoro-3-pyridinyl)-5-methyl-1H-1,2,3-triazol-4-yl]-

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: FPTQ
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: FPTQ
Price: $280.0/5mg $400.0/10mg $800.0/25mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: FPTQ
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

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FPTQ suppliers

Price: $282/10mM*1mLinDMSO

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FPTQ

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