Salicylanilide

Modify Date: 2024-01-02 13:29:46

Salicylanilide structure	Common Name	Salicylanilide
	CAS Number	87-17-2	Molecular Weight	213.232
	Density	1.3±0.1 g/cm3	Boiling Point	294.3±23.0 °C at 760 mmHg
	Molecular Formula	C₁₃H₁₁NO₂	Melting Point	136-138 °C(lit.)
	MSDS	Chinese USA	Flash Point	131.8±22.6 °C
	Symbol	GHS07, GHS09	Signal Word	Warning

Use of Salicylanilide

Salicylanilide demonstrates a wide range of biological activities including antiviral potency which can inhibit HIV virus by targeting HIV-1 integrase or reverse transcriptase.

Name	salicylanilide
Synonym	More Synonyms

Description	Salicylanilide demonstrates a wide range of biological activities including antiviral potency which can inhibit HIV virus by targeting HIV-1 integrase or reverse transcriptase.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> HIV Integrase Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection
Target	HIV-1 integrase, reverse transcriptase[1]
In Vitro	Some Salicylanilides and salicylamides could inhibit HIV virus by targeting of HIV-1 integrase or reverse transcriptase. Hepatitis C virus is another virus, which can be potentially afflicted by Salicylanilides on the level of two enzymes-NS3 protease and NS5B RNA polymerase[1].
References	[1]. Krátký M, et al. Antiviral activity of substituted salicylanilides--a review. Mini Rev Med Chem. 2011 Oct;11(11):956-67.

Density	1.3±0.1 g/cm3
Boiling Point	294.3±23.0 °C at 760 mmHg
Melting Point	136-138 °C(lit.)
Molecular Formula	C₁₃H₁₁NO₂
Molecular Weight	213.232
Flash Point	131.8±22.6 °C
Exact Mass	213.078979
PSA	49.33000
LogP	3.27
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.676
Water Solubility	SLIGHTLY SOLUBLE

Salicylanilide MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VN7850000

CHEMICAL NAME :: Salicylanilide

CAS REGISTRY NUMBER :: 87-17-2

BEILSTEIN REFERENCE NO. :: 1108135

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C13-H11-N-O2

MOLECULAR WEIGHT :: 213.25

WISWESSER LINE NOTATION :: QR BVMR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,663,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRMCE8 Farmaco. (Societa Chimica Italiana, Corso Strada Nova, 86, Casella Postale 227, 27100 Pavia, Italy) V.44- 1989- Volume(issue)/page/year: 44,465,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82917 No. of Facilities: 178 (estimated) No. of Industries: 7 No. of Occupations: 5 No. of Employees: 837 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82917 No. of Facilities: 637 (estimated) No. of Industries: 10 No. of Occupations: 14 No. of Employees: 27279 (estimated) No. of Female Employees: 21161 (estimated)

Symbol	GHS07, GHS09
Signal Word	Warning
Hazard Statements	H315-H319-H335-H400
Precautionary Statements	P261-P273-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S37/39
RIDADR	UN 3077 9 / PGIII
WGK Germany	2
RTECS	VN7850000
HS Code	29242995

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

A closer study of peak distortions in supercritical fluid chromatography as generated by the injection.

J. Chromatogr. A. 1400 , 131-9, (2015)

In SFC the sample cannot be dissolved in the mobile phase, so it is often dissolved in pure modifier, or another liquid, sometimes resulting in serious distortions of the eluted peak profiles already ...

Application of reactive salicylanilide to viscose fabrics as antibacterial and antifungus finishing.

Int. J. Biol. Macromol. 50(1) , 273-6, (2012)

In the present study salicylanilide was reacted with 2,4,6-trichloro-1,3,5-triazine producing reactive salicylanilide at a yield of 45% according to reaction conditions set. The reactive salicylanilid...

Harmaline-resistant mutant of Methanothermobacter thermautotrophicus with a lesion in Na(+)/H(+) antiport.

Gen. Physiol. Biophys. 30 Spec No , S54-60, (2011)

A spontaneous mutant of Methanothermobacter thermautotrophicus resistant to the Na(+)/H(+) antiporter inhibitor harmaline was isolated. The Na(+)/H(+) exchange activity in the mutant cells was remarka...

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Salicylanilide
Price: Click To Check
Purity: 99.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Salicylanilide
Price: ￥538.0/100g ￥218.0/25g
Purity: 98.0%
Delivery: 2 Day
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: Salicylanilide
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Salicylanilide
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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