XL-281
Modify Date: 2024-01-06 15:00:49
XL-281 structure
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Common Name | XL-281 | ||
|---|---|---|---|---|
| CAS Number | 870603-16-0 | Molecular Weight | 462.885 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C24H19ClN4O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of XL-281XL-281 (BMS 908662) is a potent, selective, orally active inhibitor of wild-type and mutant RAF kinases with anti-tumor activity in multiple xenograft models; demonstrates biological activity by modulation of the RAF pathway in tumor and surrogate tissue, with decreases in cell proliferation and increases in apoptosis. Colon Cancer Phase 2 Discontinued |
| Name | BMS-908662 |
|---|---|
| Synonym | More Synonyms |
| Description | XL-281 (BMS 908662) is a potent, selective, orally active inhibitor of wild-type and mutant RAF kinases with anti-tumor activity in multiple xenograft models; demonstrates biological activity by modulation of the RAF pathway in tumor and surrogate tissue, with decreases in cell proliferation and increases in apoptosis. Colon Cancer Phase 2 Discontinued |
|---|---|
| References | References 1. Callahan MK, et al. Cancer Immunol Res. 2014 Jan;2(1):70-9. 2. Belum VR, et al. Cancer. 2015 Jan 1;121(1):60-8. 3. Dickson MA, et al. Invest New Drugs. 2015 Apr;33(2):349-56. View Related Products by Target Raf Colon Cancer |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Molecular Formula | C24H19ClN4O4 |
| Molecular Weight | 462.885 |
| Exact Mass | 462.109497 |
| LogP | 5.03 |
| Index of Refraction | 1.754 |
| UNII:DW2NWI3TFN |
| Methyl {5-[2-(5-chloro-2-methylphenyl)-1-hydroxy-3-oxo-2,3-dihydro-1H-isoindol-1-yl]-1H-benzimidazol-2-yl}carbamate |
| BMS-908662 |
| Carbamic acid, N-[5-[2-(5-chloro-2-methylphenyl)-2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl]-1H-benzimidazol-2-yl]-, methyl ester |
| DW2NWI3TFN |