Amtolmetin guacil structure
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Common Name | Amtolmetin guacil | ||
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CAS Number | 87344-06-7 | Molecular Weight | 420.458 | |
Density | 1.2±0.1 g/cm3 | Boiling Point | 663.3±55.0 °C at 760 mmHg | |
Molecular Formula | C24H24N2O5 | Melting Point | 117-120ºC | |
MSDS | N/A | Flash Point | 354.9±31.5 °C |
Use of Amtolmetin guacilAmtolmetin guacil is an effective nonsteroidal anti-Inflammatory agent with pain-relieving effects. Amtolmetin guacil inhibits prostaglandin synthesis and cyclooxygenase (COX). Amtolmetin guacil can stimulate capsaicin receptors present on the gastrointestinal wall and also releases gastroprotective nitric oxide (NO). Amtolmetin guacil can be used to research knee osteoarthritis[1][2]. |
Name | 2-Methoxyphenyl 2-(2-(1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl)acetamido)acetate |
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Synonym | More Synonyms |
Description | Amtolmetin guacil is an effective nonsteroidal anti-Inflammatory agent with pain-relieving effects. Amtolmetin guacil inhibits prostaglandin synthesis and cyclooxygenase (COX). Amtolmetin guacil can stimulate capsaicin receptors present on the gastrointestinal wall and also releases gastroprotective nitric oxide (NO). Amtolmetin guacil can be used to research knee osteoarthritis[1][2]. |
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Related Catalog | |
Target |
Prostaglandin receptor, COX, NO[1][2] |
In Vitro | Amtolmetin guacil (100 μM; 0-60 min) converts to TMT (Tolmetin, HY-B1799) along with MED5 (1-methyl-5-p-methylbenzoyl-pyrrol-2-acetamido aceticacid) in rat fresh plasma and rat liver microsomal, rapidly converts to MED5 and MED5 methyl ester without yielding TMT in human fresh plasma and human liver microsomes[3]. |
In Vivo | Animal Model: Male Wistar rats[3] Dosage: 50 mg/kg Administration: p.o.; single dosage Result: Pharmacokinetic Parameters of Amtolmetin guacil in male Wistar rats[3]. AUC0-t (ng/mL·h) AUC0-∞ (ng/mL·h) Cmax (μg/mL) Tmax (h) Kel (h-1) t1/2,β (h) TMT followingAmtolmetin guacil dosing 162 ± 21.49 164 ± 22.47 81.62 ± 5.02 0.50 ± 0.00 0.28 ± 0.00 2.41 ± 0.01 |
Density | 1.2±0.1 g/cm3 |
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Boiling Point | 663.3±55.0 °C at 760 mmHg |
Melting Point | 117-120ºC |
Molecular Formula | C24H24N2O5 |
Molecular Weight | 420.458 |
Flash Point | 354.9±31.5 °C |
Exact Mass | 420.168518 |
PSA | 86.63000 |
LogP | 1.98 |
Vapour Pressure | 0.0±2.0 mmHg at 25°C |
Index of Refraction | 1.583 |
Material Safety Data Sheet
Section1. Identification of the substance Product Name: Amtolmetin guacil Synonyms: Section2. Hazards identification Harmful by inhalation, in contact with skin, and if swallowed. Section3. Composition/information on ingredients. Ingredient name:Amtolmetin guacil CAS number:87344-06-7 Section4. First aid measures Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing contaminated clothing and shoes. If irritation persists, seek medical attention. Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical attention. Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention. Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention. Section5. Fire fighting measures In the event of a fire involving this material, alone or in combination with other materials, use dry powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus should be worn. Section6. Accidental release measures Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national standards. Respiratory precaution:Wear approved mask/respirator Hand precaution:Wear suitable gloves/gauntlets Skin protection:Wear suitable protective clothing Eye protection:Wear suitable eye protection Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container for disposal. See section 12. Environmental precautions: Do not allow material to enter drains or water courses. Section7. Handling and storage Handling:This product should be handled only by, or under the close supervision of, those properly qualified in the handling and use of potentially hazardous chemicals, who should take into account the fire, health and chemical hazard data given on this sheet. Store in closed vessels. Storage: Section8. Exposure Controls / Personal protection Engineering Controls: Use only in a chemical fume hood. Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles. General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse. Section9. Physical and chemical properties Appearance:Not specified Boiling point:No data No data Melting point: Flash point:No data Density:No data Molecular formula:C24H24N2O5 Molecular weight:420.5 Section10. Stability and reactivity Conditions to avoid: Heat, flames and sparks. Materials to avoid: Oxidizing agents. Possible hazardous combustion products: Carbon monoxide, nitrogen oxides. Section11. Toxicological information No data. Section12. Ecological information No data. Section13. Disposal consideration Arrange disposal as special waste, by licensed disposal company, in consultation with local waste disposal authority, in accordance with national and regional regulations. Section14. Transportation information Non-harzardous for air and ground transportation. Section15. Regulatory information No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302, or have known CAS numbers that exceed the threshold reporting levels established by SARA Title III, Section 313. SECTION 16 - ADDITIONAL INFORMATION N/A |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Hazard Codes | Xi |
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2-Methoxyphenyl N-{[1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl]acetyl}glycinate |
amtolmetin guacil |
Glycine, N-[2-[1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl]acetyl]-, 2-methoxyphenyl ester |
MFCD00866153 |