1-[3-(trifluoromethyl)pyrid-2-yl]piperazine

Modify Date: 2024-01-11 17:37:38

1-[3-(trifluoromethyl)pyrid-2-yl]piperazine Structure
1-[3-(trifluoromethyl)pyrid-2-yl]piperazine structure
Common Name 1-[3-(trifluoromethyl)pyrid-2-yl]piperazine
CAS Number 87394-63-6 Molecular Weight 231.21800
Density 1.253g/cm3 Boiling Point 319.4ºC at 760 mmHg
Molecular Formula C10H12F3N3 Melting Point 45-47ºC
MSDS N/A Flash Point N/A

 Names

Name 1-[3-(trifluoromethyl)pyrid-2-yl]piperazine
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.253g/cm3
Boiling Point 319.4ºC at 760 mmHg
Melting Point 45-47ºC
Molecular Formula C10H12F3N3
Molecular Weight 231.21800
Exact Mass 231.09800
PSA 28.16000
LogP 1.90380

 MSDS

Name: 1-[3-(Trifluoromethyl)-2-pyridyl]piperazine 95+% Material Safety Data Sheet
Synonym:
CAS: 87394-63-6
Section 1 - Chemical Product MSDS Name:1-[3-(Trifluoromethyl)-2-pyridyl]piperazine 95+% Material Safety Data Sheet
Synonym:

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
87394-63-6 1-[3-(Trifluoromethyl)-2-pyridyl]piper 95+% unlisted
Hazard Symbols: C
Risk Phrases: 34

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Causes burns.
Potential Health Effects
Eye:
Causes eye burns.
Skin:
Causes skin burns.
Ingestion:
Causes gastrointestinal tract burns.
Inhalation:
Causes chemical burns to the respiratory tract.
Chronic:
Not available.

Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Do not induce vomiting. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:
Treat symptomatically and supportively.

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use foam, dry chemical, or carbon dioxide.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container.

Section 7 - HANDLING and STORAGE
Handling:
Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood.
Storage:
Store in a cool, dry place. Store in a tightly closed container.
Corrosives area.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 87394-63-6: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Liquid
Color: Not available.
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: 106 deg C @1.5mmHg
Freezing/Melting Point: 42 - 45 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C10H12F3N3
Molecular Weight: 231.22

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Not available.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide, fluorine, hydrogen fluoride gas.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 87394-63-6 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
1-[3-(Trifluoromethyl)-2-pyridyl]piperazine - Not listed by ACGIH, IARC, or NTP.

Section 12 - ECOLOGICAL INFORMATION


Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: AMINES, SOLID, CORROSIVE, N.O.S.*
Hazard Class: 8
UN Number: 3259
Packing Group: III
IMO
Shipping Name: AMINES, SOLID, CORROSIVE, N.O.S.
Hazard Class: 8
UN Number: 3259
Packing Group: III
RID/ADR
Shipping Name: AMINES, SOLID, CORROSIVE, N.O.S.
Hazard Class: 8
UN Number: 3259
Packing group: III

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: C
Risk Phrases:
R 34 Causes burns.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 87394-63-6: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 87394-63-6 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 87394-63-6 is not listed on the TSCA inventory.
It is for research and development use only.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Safety Information

Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases 26-36/37/39

 Synthetic Route

~99%

1-[3-(trifluoromethyl)pyrid-2-yl]piperazine Structure

1-[3-(trifluoro...

CAS#:87394-63-6

Literature: Xiang, Jason; Wan, Zhao-Kui; Li, Huan-Qiu; Ipek, Manus; Binnun, Eva; Nunez, Jill; Chen, Lihren; McKew, John C.; Mansour, Tarek S.; Xu, Xin; Suri, Vipin; Tam, May; Xing, Yuzhe; Li, Xiangping; Hahm, Seung; Tobin, James; Saiah, Eddine Journal of Medicinal Chemistry, 2008 , vol. 51, # 14 p. 4068 - 4071

~78%

1-[3-(trifluoromethyl)pyrid-2-yl]piperazine Structure

1-[3-(trifluoro...

CAS#:87394-63-6

Literature: Swanson, Devin M.; Dubin, Adrienne E.; Shah, Chandra; Nasser, Nadia; Chang, Leon; Dax, Scott L.; Jetter, Michele; Breitenbucher, J. Guy; Liu, Changlu; Mazur, Curt; Lord, Brian; Gonzales, Lisa; Hoey, Kenway; Rizzolio, Michele; Bogenstaetter, Michael; Codd, Ellen E.; Lee, Doo H.; Zhang, Sui-Po; Chaplan, Sandra R.; Carruthers, Nicholas I. Journal of Medicinal Chemistry, 2005 , vol. 48, # 6 p. 1857 - 1872

~83%

1-[3-(trifluoromethyl)pyrid-2-yl]piperazine Structure

1-[3-(trifluoro...

CAS#:87394-63-6

Literature: Bristol-Myers Squibb Company Patent: US4954502 A1, 1990 ;

~%

1-[3-(trifluoromethyl)pyrid-2-yl]piperazine Structure

1-[3-(trifluoro...

CAS#:87394-63-6

Literature: Journal of Medicinal Chemistry, , vol. 26, # 12 p. 1696 - 1701

 Synonyms

MFCD00114705
Top Suppliers:I want be here


Get all suppliers and price by the below link:

1-[3-(trifluoromethyl)pyrid-2-yl]piperazine suppliers


Price: ¥936/5g

Reference only. check more 1-[3-(trifluoromethyl)pyrid-2-yl]piperazine price

Related Compounds: More...
1-[3-(trifluoromethyl)pyrid-2-yl]piperazine
87394-50-1
1-[3-(TRIFLUOROMETHYL)PYRID-2-YL]-1,4-DIAZEPANE
243666-15-1
1-[3-chloro-5-(trifluoromethyl)pyrid-2-yl]piperazine
132834-59-4
1-[3-CHLORO-5-(TRIFLUOROMETHYL)PYRID-2-YL]-4-(ETHOXYCARBONYLMETHYL)-3-THIOSEMICARBAZIDE
321433-74-3
BI-5-(1-(3-CHLORO-5-(TRIFLUOROMETHYL)PYRID-2-YL)-3-METHYL-1H-PYRAZOLE)-4'-(1-PHENYL-1H-5-PYRAZOLOL)
318951-76-7
(R)-3-METHYL-1-(3-(TRIFLUOROMETHYL)PYRIDIN-2-YL)PIPERAZINE
582325-05-1
1-(α-Methyl-m-trifluoromethylphenethyl)piperazine
74037-99-3
3-CHLORO-2-(1-METHYLHYDRAZINYL)-5-(TRIFLUOROMETHYL)PYRIDINE
138949-13-0
ETHYL 4-METHYL-2-[5-(TRIFLUOROMETHYL)PYRID-2-YL]THIAZOLE-5-CARBOXYLATE 97
175277-54-0
5-{[(9H-fluoren-9-yl)methoxy]carbonyl}-2-oxa-5-azabicyclo[2.2.1]heptane-1-carboxylic acid
2639407-38-6
(4-Ethynyl-2-(3-methoxypropoxy)phenyl)methanamine
2890774-57-7
1-[5-(2-fluorophenyl)-1-methyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]-3-(1-phenylcyclopropyl)urea
2624115-37-1
2-(4-{[(Tert-butoxy)carbonyl]amino}-2-methyloxan-4-yl)acetic acid
2140059-60-3
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1158522-08-7
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
940364-43-2
Benzenamine, 4-[2-(2,5-dichlorophenyl)diazenyl]-N,N,2-trimethyl-
101353-35-9
1-[(1-Ethynylcyclopropyl)methyl]-2,4,5-trifluorobenzene
2228372-46-9
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
134104-43-1
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
131615-57-1