1-[3-(trifluoromethyl)pyrid-2-yl]piperazine structure
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Common Name | 1-[3-(trifluoromethyl)pyrid-2-yl]piperazine | ||
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CAS Number | 87394-63-6 | Molecular Weight | 231.21800 | |
Density | 1.253g/cm3 | Boiling Point | 319.4ºC at 760 mmHg | |
Molecular Formula | C10H12F3N3 | Melting Point | 45-47ºC | |
MSDS | N/A | Flash Point | N/A |
Name | 1-[3-(trifluoromethyl)pyrid-2-yl]piperazine |
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Synonym | More Synonyms |
Density | 1.253g/cm3 |
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Boiling Point | 319.4ºC at 760 mmHg |
Melting Point | 45-47ºC |
Molecular Formula | C10H12F3N3 |
Molecular Weight | 231.21800 |
Exact Mass | 231.09800 |
PSA | 28.16000 |
LogP | 1.90380 |
Synonym: Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
Risk Phrases: 34 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW
Causes burns. Potential Health Effects Eye: Causes eye burns. Skin: Causes skin burns. Ingestion: Causes gastrointestinal tract burns. Inhalation: Causes chemical burns to the respiratory tract. Chronic: Not available. Section 4 - FIRST AID MEASURES Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Skin: Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Ingestion: Do not induce vomiting. Get medical aid immediately. Inhalation: Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Notes to Physician: Treat symptomatically and supportively. Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing Media: Use foam, dry chemical, or carbon dioxide. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Section 7 - HANDLING and STORAGE Handling: Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood. Storage: Store in a cool, dry place. Store in a tightly closed container. Corrosives area. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 87394-63-6: Personal Protective Equipment Eyes: Not available. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Liquid Color: Not available. Odor: Not available. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: 106 deg C @1.5mmHg Freezing/Melting Point: 42 - 45 deg C Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Specific Gravity/Density: Molecular Formula: C10H12F3N3 Molecular Weight: 231.22 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Not available. Conditions to Avoid: Incompatible materials. Incompatibilities with Other Materials: Strong oxidizing agents. Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide, fluorine, hydrogen fluoride gas. Hazardous Polymerization: Has not been reported Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 87394-63-6 unlisted. LD50/LC50: Not available. Carcinogenicity: 1-[3-(Trifluoromethyl)-2-pyridyl]piperazine - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Shipping Name: AMINES, SOLID, CORROSIVE, N.O.S.* Hazard Class: 8 UN Number: 3259 Packing Group: III IMO Shipping Name: AMINES, SOLID, CORROSIVE, N.O.S. Hazard Class: 8 UN Number: 3259 Packing Group: III RID/ADR Shipping Name: AMINES, SOLID, CORROSIVE, N.O.S. Hazard Class: 8 UN Number: 3259 Packing group: III Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: C Risk Phrases: R 34 Causes burns. Safety Phrases: S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36/37/39 Wear suitable protective clothing, gloves and eye/face protection. S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). WGK (Water Danger/Protection) CAS# 87394-63-6: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 87394-63-6 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 87394-63-6 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A |
Hazard Codes | Xi |
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Risk Phrases | R36/37/38 |
Safety Phrases | 26-36/37/39 |
~99% 1-[3-(trifluoro... CAS#:87394-63-6 |
Literature: Xiang, Jason; Wan, Zhao-Kui; Li, Huan-Qiu; Ipek, Manus; Binnun, Eva; Nunez, Jill; Chen, Lihren; McKew, John C.; Mansour, Tarek S.; Xu, Xin; Suri, Vipin; Tam, May; Xing, Yuzhe; Li, Xiangping; Hahm, Seung; Tobin, James; Saiah, Eddine Journal of Medicinal Chemistry, 2008 , vol. 51, # 14 p. 4068 - 4071 |
~78% 1-[3-(trifluoro... CAS#:87394-63-6 |
Literature: Swanson, Devin M.; Dubin, Adrienne E.; Shah, Chandra; Nasser, Nadia; Chang, Leon; Dax, Scott L.; Jetter, Michele; Breitenbucher, J. Guy; Liu, Changlu; Mazur, Curt; Lord, Brian; Gonzales, Lisa; Hoey, Kenway; Rizzolio, Michele; Bogenstaetter, Michael; Codd, Ellen E.; Lee, Doo H.; Zhang, Sui-Po; Chaplan, Sandra R.; Carruthers, Nicholas I. Journal of Medicinal Chemistry, 2005 , vol. 48, # 6 p. 1857 - 1872 |
~83% 1-[3-(trifluoro... CAS#:87394-63-6 |
Literature: Bristol-Myers Squibb Company Patent: US4954502 A1, 1990 ; |
~% 1-[3-(trifluoro... CAS#:87394-63-6 |
Literature: Journal of Medicinal Chemistry, , vol. 26, # 12 p. 1696 - 1701 |
MFCD00114705 |