5-Chloro-2-(piperazin-1-yl)pyridine

Modify Date: 2024-01-04 18:21:57

5-Chloro-2-(piperazin-1-yl)pyridine Structure
5-Chloro-2-(piperazin-1-yl)pyridine structure
Common Name 5-Chloro-2-(piperazin-1-yl)pyridine
CAS Number 87394-65-8 Molecular Weight 197.66500
Density 1.213g/cm3 Boiling Point 351.5ºC at 760 mmHg
Molecular Formula C9H12ClN3 Melting Point N/A
MSDS USA Flash Point 166.4ºC

 Names

Name 1-(5-chloropyridin-2-yl)piperazine
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.213g/cm3
Boiling Point 351.5ºC at 760 mmHg
Molecular Formula C9H12ClN3
Molecular Weight 197.66500
Flash Point 166.4ºC
Exact Mass 197.07200
PSA 28.16000
LogP 1.53840
Index of Refraction 1.561

 MSDS

Material Safety Data Sheet

Section1. Identification of the substance
1-(5-Chloropyridin-2-yl)piperazine
Product Name:
Synonyms:

Section2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.
H315:Causes skin irritation
H319:Causes serious eye irritation
H335:May cause respiratory irritation
P261:Avoid breathing dust/fume/gas/mist/vapours/spray
Wear protective gloves/protective clothing/eye protection/face protection
P280:
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present
and easy to do – continue rinsing
P304+P340:IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing
P405:Store locked up

Section3. Composition/information on ingredients.
1-(5-Chloropyridin-2-yl)piperazine
Ingredient name:
CAS number:87394-65-8

Section4. First aid measures
Immediately wash skin with copious amounts of water for at least 15 minutes while removing
Skin contact:
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.
Ingestion:

Section5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

Section7. Handling and storage
Handling:This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Storage:Store in closed vessels, refrigerated.

Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section9. Physical and chemical properties
Not specified
Appearance:
Boiling point:No data
Melting point:No data
Flash point:No data
Density:No data
Molecular formula:C9H12ClN3
Molecular weight:197.7

Section10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride.

Section11. Toxicological information
No data.

Section12. Ecological information
No data.

Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

Section14. Transportation information
Non-harzardous for air and ground transportation.

Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Safety Information

Hazard Codes T
Risk Phrases 25
Safety Phrases 45
HS Code 2933990090

 Synthetic Route

~99%

5-Chloro-2-(piperazin-1-yl)pyridine Structure

5-Chloro-2-(pip...

CAS#:87394-65-8

Literature: SK Chemicals Co.,Ltd.; RYU, Je Ho; KIM, Shin Ae; RYU, Keun Ho; KIM, Jae Sun; KIM, Nam Ho; HAN, Hye Young; KIM, Yong Hyuk; YOUN, Won-No; LEE, Yoon-Jung; SON, Hyun Joo; LEE, Bong-yong; PARK, Sung Hoon; LEE, Ju Young; LEE, Hyun Jung; JUNG, Hoe Chul; SHIN, Young Ah; LEE, Jung A; LEE, Bo Ram; SA, Joon Ho Patent: WO2011/139107 A2, 2011 ; Location in patent: Page/Page column 39 ; WO 2011/139107 A2

~89%

5-Chloro-2-(piperazin-1-yl)pyridine Structure

5-Chloro-2-(pip...

CAS#:87394-65-8

Literature: Merck Sharpe and Dohme Ltd. Patent: US5432177 A1, 1995 ;

~%

5-Chloro-2-(piperazin-1-yl)pyridine Structure

5-Chloro-2-(pip...

CAS#:87394-65-8

Literature: Journal of Medicinal Chemistry, , vol. 26, # 12 p. 1696 - 1701

~%

5-Chloro-2-(piperazin-1-yl)pyridine Structure

5-Chloro-2-(pip...

CAS#:87394-65-8

Literature: Journal of Medicinal Chemistry, , vol. 26, # 12 p. 1696 - 1701

~%

5-Chloro-2-(piperazin-1-yl)pyridine Structure

5-Chloro-2-(pip...

CAS#:87394-65-8

Literature: WO2011/139107 A2, ; WO 2011/139107 A2

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

1-(5-CHLORO-2-PYRIDINYL)PIPERAZINE
1-(5-Chloro-2-pyridyl)piperazine
5-Chloro-2-(piperazin-1-yl)pyridine
4-(5-chloropyridin-2-yl)piperazine
1-(5-Chloro-pyridin-2-yl)piperazine
MFCD04115049
2-piperazino 5-chloro pyridine
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