1,3-Dimethyluracil

Modify Date: 2024-01-02 11:53:21

1,3-Dimethyluracil structure	Common Name	1,3-Dimethyluracil
	CAS Number	874-14-6	Molecular Weight	140.140
	Density	1.2±0.1 g/cm3	Boiling Point	208.4±23.0 °C at 760 mmHg
	Molecular Formula	C₆H₈N₂O₂	Melting Point	119-122 °C(lit.)
	MSDS	Chinese USA	Flash Point	84.3±15.0 °C

Use of 1,3-Dimethyluracil

1,3-Dimethyluracil is a pyrimidone derives from a uracil. 1,3-Dimethyluracil found occasionally in human urine. 1,3-Dimethyluracil shows inhibition activity against hCA I and hCA II (human carbonic anhydrase) with Ki of 316.2 μM and 166.4 μM, respectively[1][2].

Name	1,3-Dimethyluracil
Synonym	More Synonyms

Description	1,3-Dimethyluracil is a pyrimidone derives from a uracil. 1,3-Dimethyluracil found occasionally in human urine. 1,3-Dimethyluracil shows inhibition activity against hCA I and hCA II (human carbonic anhydrase) with Ki of 316.2 μM and 166.4 μM, respectively[1][2].
Related Catalog	Research Areas >> Metabolic Disease
References	[1]. Stoessel D, et al. Promising Metabolite Profiles in the Plasma and CSF of Early Clinical Parkinson's Disease. Front Aging Neurosci. 2018 Mar 5;10:51. [2]. Güney M, et al. Synthesis and carbonic anhydrase inhibitory properties of novel uracil derivatives. Bioorg Med Chem Lett. 2015 Aug 15;25(16):3261-3.

Description

Related Catalog

Research Areas >> Metabolic Disease

References

[1]. Stoessel D, et al. Promising Metabolite Profiles in the Plasma and CSF of Early Clinical Parkinson's Disease. Front Aging Neurosci. 2018 Mar 5;10:51.

[2]. Güney M, et al. Synthesis and carbonic anhydrase inhibitory properties of novel uracil derivatives. Bioorg Med Chem Lett. 2015 Aug 15;25(16):3261-3.

Density	1.2±0.1 g/cm3
Boiling Point	208.4±23.0 °C at 760 mmHg
Melting Point	119-122 °C(lit.)
Molecular Formula	C₆H₈N₂O₂
Molecular Weight	140.140
Flash Point	84.3±15.0 °C
Exact Mass	140.058578
PSA	44.00000
LogP	0.40
Vapour Pressure	0.2±0.4 mmHg at 25°C
Index of Refraction	1.519

1,3-Dimethyluracil MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi:Irritant;
Risk Phrases	R36
Safety Phrases	S22-S24/25-S39-S26
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2933599090

Precursor 9
CAS#:66-22-8 Uracil CAS#:77-78-1 Dimethyl sulfate CAS#:7033-39-8 5-Bromo-1,3-dim... CAS#:616-38-6 Dimethyl Carbonate
CAS#:74-88-4 methyl iodide CAS#:74-83-9 Methyl bromide CAS#:83174-90-7 1,3-dimethyl-2,... CAS#:10504-60-6 Methyl(diphenyl...
CAS#:32894-07-8 BENZYL THIOACET...
DownStream 10
CAS#:104556-86-7 Ethyl 4,7-dihyd... CAS#:104556-85-6 3-methyl-4h-pyr... CAS#:35441-10-2 2,6-dihydroxy-3... CAS#:35441-11-3 2,6-dihydroxyni...
CAS#:41613-26-7 2,4(1H,3H)-Pyri... CAS#:40738-83-8 5-iodo-1,3-dime... CAS#:96-31-1 1,3-Dimethylurea CAS#:57821-20-2 8,10-dimethyl-2...
CAS#:58-55-9 Theophylline CAS#:7033-39-8 5-Bromo-1,3-dim...

HS Code	2933599090
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Excited state structures and decay dynamics of 1,3-dimethyluracils in solutions: resonance Raman and quantum mechanical calculation study.

J. Phys. Chem. B 117(39) , 11660-9, (2013)

The resonance Raman spectroscopic study of the excited state structural dynamics of 1,3-dimethyluracil (DMU), 5-bromo-1,3-dimethyluracil (5BrDMU), uracil, and thymine in water and acetonitrile were re...

Ionization of dimethyluracil dimers leads to facile proton transfer in the absence of hydrogen bonds.

Nature Chemistry 4(4) , 323-9, (2012)

Proton transfer is ubiquitous in chemistry and biology, occurring, for example, in proteins, enzyme reactions and across proton channels and pumps. However, it has always been described in the context...

The SO4(.-)-induced chain reaction of 1,3-dimethyluracil with peroxodisulphate.

Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 51(3) , 441-53, (1987)

The sulphate radical SO4(.-) reacts with 1,3-dimethyluracil (1,3-DMU) (k = 5 X 10(9) dm3 mol-1 s-1) thereby forming with greater than or equal to 90 per cent yield the 1,3-DMU C(5)-OH adduct radical 4...

N1,N3-Dimethyluracil

1,3-dimethylpyrimidine-2,4-dione

2,4(1H,3H)-Pyrimidinedione, 1,3-dimethyl-

1,3-Dimethyl-2,4(1H,3H)-pyrimidinedione

MFCD00038065

1,3-dimethyluracil

Uracil, 1,3-dimethyl-

1,3-dimethylpyrimidine-2,4(1H,3H)-dione

EINECS 212-856-4