Thiocolchicine analog

Modify Date: 2024-01-21 18:26:37

Thiocolchicine analog structure	Common Name	Thiocolchicine analog
	CAS Number	87424-26-8	Molecular Weight	401.47600
	Density	1.33g/cm3	Boiling Point	766.8ºC at 760 mmHg
	Molecular Formula	C₂₁H₂₃NO₅S	Melting Point	218-220ºC
	MSDS	N/A	Flash Point	417.6ºC

Name	N-[(7S)-2-hydroxy-1,3-dimethoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
Synonym	More Synonyms

Density	1.33g/cm3
Boiling Point	766.8ºC at 760 mmHg
Melting Point	218-220ºC
Molecular Formula	C₂₁H₂₃NO₅S
Molecular Weight	401.47600
Flash Point	417.6ºC
Exact Mass	401.13000
PSA	110.16000
LogP	3.67280
Index of Refraction	1.636

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GH0882000

CHEMICAL NAME :: Colchicine, O(sup 2)-demethyl-10-thio-

CAS REGISTRY NUMBER :: 87424-26-8

BEILSTEIN REFERENCE NO. :: 3176298

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C21-H23-N-O5-S

MOLECULAR WEIGHT :: 401.51

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intracerebral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 25 ug/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 109,386,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 109,386,1957

Thiocolchicine structure

Thiocolchicine

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~3%

Thiocolchicine analog Structure

Thiocolchicine ...

CAS#:87424-26-8

2,3-didemethylthiocolchicine structure

2,3-didemethylt...

CAS#:51296-12-9

10-demethoxy-1-O,2-O-didemethyl-10-(methylthio)colchicine structure

10-demethoxy-1-...

CAS#:51296-11-8

Literature: Guan, Jian; Brossi, Arnold; Zhu, Xiao-Kang; Wang, Hui-Kang; Lee, Kuo-Hsiung Synthetic Communications, 1998 , vol. 28, # 9 p. 1585 - 1591

2,3-didemethylthiocolchicine structure

2,3-didemethylt...

CAS#:51296-12-9

(Trimethylsilyl)diazomethane structure

(Trimethylsilyl...

CAS#:18107-18-1

~%

Thiocolchicine analog Structure

Thiocolchicine ...

CAS#:87424-26-8

3-demethylthiocolchicine structure

3-demethylthioc...

CAS#:87424-25-7

Literature: Nakagawa-Goto, Kyoko; Chen, Cyril X.; Hamel, Ernest; Wu, Chin-Chung; Bastow, Kenneth F.; Brossi, Arnold; Lee, Kuo-Hsiung Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 1 p. 235 - 238

Precursor 3
CAS#:2730-71-4 Thiocolchicine CAS#:51296-12-9 2,3-didemethylt... CAS#:18107-18-1 (Trimethylsilyl...
DownStream 0

N-((S)-2-hydroxy-1,3-dimethoxy-10-methylsulfanyl-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamide

N-((S)-2-Hydroxy-1,3-dimethoxy-10-methylmercapto-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamid

2-Demethyl Thiocolchicine

COLCHICINE,O(sup 2)-DEMETHYL-10-THIO

(S)-7-Acetylamino-2-hydroxy-1,3-dimethoxy-10-methylmercapto-6,7-dihydro-5H-benzo[a]heptalen-9-on

O(sup 2)-Demethyl-10-thiocolchicine

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Thiocolchicine analog
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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