LY 2318912

Modify Date: 2024-01-08 20:04:24

LY 2318912 Structure
LY 2318912 structure
Common Name LY 2318912
CAS Number 874902-18-8 Molecular Weight 441.193
Density N/A Boiling Point N/A
Molecular Formula C12H12IN9O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of LY 2318912


LY 2318912 is a potent, competitive, small molecule inhibitor of anandamide uptake with IC50 of 7.27 nM, shows high affinity against anandamide transporter binding site with Kd o f7.62 nM; elevates anandamide levels 5-fold in the brain and demonstrates efficacy in the formalin paw-licking model of persistent pain with no obvious adverse effects on motor function in rodents.

 Names

Name LY 2318912

 LY 2318912 Biological Activity

Description LY 2318912 is a potent, competitive, small molecule inhibitor of anandamide uptake with IC50 of 7.27 nM, shows high affinity against anandamide transporter binding site with Kd o f7.62 nM; elevates anandamide levels 5-fold in the brain and demonstrates efficacy in the formalin paw-licking model of persistent pain with no obvious adverse effects on motor function in rodents.
References References 1. Moore SA, et al. Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17852-7. 2. Ortar G, et al. Eur J Med Chem. 2008 Jan;43(1):62-72. View Related Products by Target FAAH

 Chemical & Physical Properties

Molecular Formula C12H12IN9O2
Molecular Weight 441.193
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