MK-0448
Modify Date: 2024-01-14 18:18:25
MK-0448 structure
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Common Name | MK-0448 | ||
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| CAS Number | 875562-81-5 | Molecular Weight | 448.516 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H21FN4O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MK-0448MK-0448 is a potent, specific I(Kur) current/Kv1.5 channel inhibitor with IC50 of 8.6 nM, potently inhibits IKur in human atrial myocytes with IC50 of 10.8 nM; also demonstrates a potent effect on currents associated with other Kv1.x and Kv2.x subunits, such as Kv1.7 and Kv2.1, with IC50 of 72 and 61 nM, respectively; displays >70-fold concentration than inhibition of IKur; significantly causes prolongation of the atrial refractory period in normal anesthetized dogs. Heart Arrhythmia Phase 1 Clinical |
| Name | MK-0448 |
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| Description | MK-0448 is a potent, specific I(Kur) current/Kv1.5 channel inhibitor with IC50 of 8.6 nM, potently inhibits IKur in human atrial myocytes with IC50 of 10.8 nM; also demonstrates a potent effect on currents associated with other Kv1.x and Kv2.x subunits, such as Kv1.7 and Kv2.1, with IC50 of 72 and 61 nM, respectively; displays >70-fold concentration than inhibition of IKur; significantly causes prolongation of the atrial refractory period in normal anesthetized dogs. Heart Arrhythmia Phase 1 Clinical |
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| References | References 1. Pavri BB, et al. Circ Arrhythm Electrophysiol. 2012 Dec;5(6):1193-201. 2. Loose S, et al. Front Pharmacol. 2014 Mar 4;5:26. 3. Wolkenberg SE, et al. Bioorg Med Chem Lett. 2017 Feb 15;27(4):1062-1069. View Related Products by Target Potassium Channel Heart Arrhythmia |
| Molecular Formula | C24H21FN4O2S |
|---|---|
| Molecular Weight | 448.516 |