3-bromo-1,1,1-trifluoro-2-propanol

Modify Date: 2024-01-19 18:56:55

3-bromo-1,1,1-trifluoro-2-propanol Structure
3-bromo-1,1,1-trifluoro-2-propanol structure
Common Name 3-bromo-1,1,1-trifluoro-2-propanol
CAS Number 88378-50-1 Molecular Weight 192.96200
Density 1.861 g/mL at 25ºC(lit.) Boiling Point 124.5ºC743 mm Hg(lit.)
Molecular Formula C3H4BrF3O Melting Point N/A
MSDS N/A Flash Point 110 °F

 Names

Name 3-bromo-1,1,1-trifluoro-2-propanol
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.861 g/mL at 25ºC(lit.)
Boiling Point 124.5ºC743 mm Hg(lit.)
Molecular Formula C3H4BrF3O
Molecular Weight 192.96200
Flash Point 110 °F
Exact Mass 191.94000
PSA 20.23000
LogP 1.30450
Index of Refraction n20/D 1.4(lit.)

 MSDS

Name: 3-Bromo-1 1 1-trifluoro-2-propanol 96% (g c) Material Safety Data Sheet
Synonym: 3-Bromo-1,1,1-trifluoroisopropano
CAS: 88378-50-1
Section 1 - Chemical Product MSDS Name:3-Bromo-1 1 1-trifluoro-2-propanol 96% (g c) Material Safety Data Sheet
Synonym:3-Bromo-1,1,1-trifluoroisopropano

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
88378-50-1 3-Bromo-1,1,1-trifluoro-2-propanol 96 unlisted
Hazard Symbols: XI
Risk Phrases: 36/37/38

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Irritating to eyes, respiratory system and skin.The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
Causes skin irritation.
Ingestion:
The toxicological properties of this substance have not been fully investigated.
Inhalation:
Causes respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
Not available.

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container.

Section 7 - HANDLING and STORAGE
Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 88378-50-1: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Liquid
Color: clear, colorless
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: 124 - 126 deg C @ 760.00mm Hg
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C3H4BrF3O
Molecular Weight: 192.96

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Not available.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Strong oxidizing agents - strong reducing agents - strong acids - strong bases.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide, hydrogen fluoride gas, hydrogen bromide.
Hazardous Polymerization: Has not been reported.

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 88378-50-1 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
3-Bromo-1,1,1-trifluoro-2-propanol - Not listed by ACGIH, IARC, or NTP.

Section 12 - ECOLOGICAL INFORMATION


Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI
Risk Phrases:
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 37/39 Wear suitable gloves and eye/face
protection.
WGK (Water Danger/Protection)
CAS# 88378-50-1: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 88378-50-1 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 88378-50-1 is not listed on the TSCA inventory.
It is for research and development use only.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Safety Information

Hazard Codes Xi: Irritant;
Risk Phrases 36/37/38
Safety Phrases 26-36
RIDADR UN 1987 3/PG 3
WGK Germany 3
HS Code 2905590090

 Synthetic Route

~15%

3-bromo-1,1,1-trifluoro-2-propanol Structure

3-bromo-1,1,1-t...

CAS#:88378-50-1

Literature: Bucciarelli, Maria; Forni. Arrigo; Moretti, Irene; Torre, Giovanni Synthesis, 1983 , # 11 p. 897 - 899

 Precursor & DownStream

Precursor  1

DownStream  0

 Customs

HS Code 2905590090
Summary 2905590090 other halogenated, sulphonated, nitrated or nitrosated derivatives of acyclic alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

 Synonyms

Fmoc-4-phenyl-phenylalanine
Fmoc-L-4-phenyl-phenylalanine
(S)-3-biphenyl-4-yl-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionic acid
(S)-2-(benzyloxycarbonylamino)succinimide
(S)-3-Bromo-1,1,1-trifluoro-2-propanol
(S)-(+)-1-Bromo-3,3,3-trifluoro-2-propanol
(S)-3-benzyloxycarbonylaminopyrrolidine-2,5-dione
N-benzyloxycarbonyl-L-aspartic acid imide
Fmoc-Bip-OH
(S)-3-N-carbobenzyloxyaminosuccinimide
(S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(biphenyl-4-yl)propanoic acid
(3S)-3-(benzyloxycarbonylamino)succinimide
MFCD00040945
3-(S)-N-benzyloxycarbonylaminopyrrolidine-2,5-dione
Fmoc-4-phenyl-L-alanine
(s)-(2,5-dioxo-pyrrolidin-3-yl)-carbamic acid benzyl ester
(S)-3-N-Cbz-amino-succinimide
(S)-benzyl 2,5-dioxopyrrolidin-3-ylcarbamate
Fmoc-(p-Phe)Phe-OH
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