JNJ-28312141
JNJ-28312141 structure
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Common Name | JNJ-28312141 | ||
|---|---|---|---|---|
| CAS Number | 885692-52-4 | Molecular Weight | 460.571 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C26H32N6O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of JNJ-28312141JNJ-28312141 is an orally active CSF1R inhibitor (Colony-stimulating factor-1 receptor, CRF1R) and also a FLT3 inhibitor. |
| Name | 5-cyano-N-[2-(cyclohexen-1-yl)-4-[1-[2-(dimethylamino)acetyl]piperidin-4-yl]phenyl]-1H-imidazole-2-carboxamide |
|---|---|
| Synonym | More Synonyms |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C26H32N6O2 |
| Molecular Weight | 460.571 |
| Exact Mass | 460.258667 |
| PSA | 105.12000 |
| LogP | 2.72 |
| Index of Refraction | 1.632 |
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JNJ-28312141 CAS#:885692-52-4 |
| Literature: Illig, Carl R.; Manthey, Carl L.; Wall, Mark J.; Meegalla, Sanath K.; Chen, Jinsheng; Wilson, Kenneth J.; Ballentine, Shelley K.; Desjarlais, Renee L.; Schubert, Carsten; Crysler, Carl S.; Chen, Yanmin; Molloy, Christopher J.; Chaikin, Margery A.; Donatelli, Robert R.; Yurkow, Edward; Zhou, Zhao; Player, Mark R.; Tomczuk, Bruce E. Journal of Medicinal Chemistry, 2011 , vol. 54, # 22 p. 7860 - 7883 |
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JNJ-28312141 CAS#:885692-52-4 |
| Literature: Illig, Carl R.; Manthey, Carl L.; Wall, Mark J.; Meegalla, Sanath K.; Chen, Jinsheng; Wilson, Kenneth J.; Ballentine, Shelley K.; Desjarlais, Renee L.; Schubert, Carsten; Crysler, Carl S.; Chen, Yanmin; Molloy, Christopher J.; Chaikin, Margery A.; Donatelli, Robert R.; Yurkow, Edward; Zhou, Zhao; Player, Mark R.; Tomczuk, Bruce E. Journal of Medicinal Chemistry, 2011 , vol. 54, # 22 p. 7860 - 7883 |
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JNJ-28312141 CAS#:885692-52-4 |
| Literature: Illig, Carl R.; Manthey, Carl L.; Wall, Mark J.; Meegalla, Sanath K.; Chen, Jinsheng; Wilson, Kenneth J.; Ballentine, Shelley K.; Desjarlais, Renee L.; Schubert, Carsten; Crysler, Carl S.; Chen, Yanmin; Molloy, Christopher J.; Chaikin, Margery A.; Donatelli, Robert R.; Yurkow, Edward; Zhou, Zhao; Player, Mark R.; Tomczuk, Bruce E. Journal of Medicinal Chemistry, 2011 , vol. 54, # 22 p. 7860 - 7883 |
|
~%
JNJ-28312141 CAS#:885692-52-4 |
| Literature: Illig, Carl R.; Manthey, Carl L.; Wall, Mark J.; Meegalla, Sanath K.; Chen, Jinsheng; Wilson, Kenneth J.; Ballentine, Shelley K.; Desjarlais, Renee L.; Schubert, Carsten; Crysler, Carl S.; Chen, Yanmin; Molloy, Christopher J.; Chaikin, Margery A.; Donatelli, Robert R.; Yurkow, Edward; Zhou, Zhao; Player, Mark R.; Tomczuk, Bruce E. Journal of Medicinal Chemistry, 2011 , vol. 54, # 22 p. 7860 - 7883 |
|
~%
JNJ-28312141 CAS#:885692-52-4 |
| Literature: Illig, Carl R.; Manthey, Carl L.; Wall, Mark J.; Meegalla, Sanath K.; Chen, Jinsheng; Wilson, Kenneth J.; Ballentine, Shelley K.; Desjarlais, Renee L.; Schubert, Carsten; Crysler, Carl S.; Chen, Yanmin; Molloy, Christopher J.; Chaikin, Margery A.; Donatelli, Robert R.; Yurkow, Edward; Zhou, Zhao; Player, Mark R.; Tomczuk, Bruce E. Journal of Medicinal Chemistry, 2011 , vol. 54, # 22 p. 7860 - 7883 |
|
~%
JNJ-28312141 CAS#:885692-52-4 |
| Literature: Illig, Carl R.; Manthey, Carl L.; Wall, Mark J.; Meegalla, Sanath K.; Chen, Jinsheng; Wilson, Kenneth J.; Ballentine, Shelley K.; Desjarlais, Renee L.; Schubert, Carsten; Crysler, Carl S.; Chen, Yanmin; Molloy, Christopher J.; Chaikin, Margery A.; Donatelli, Robert R.; Yurkow, Edward; Zhou, Zhao; Player, Mark R.; Tomczuk, Bruce E. Journal of Medicinal Chemistry, 2011 , vol. 54, # 22 p. 7860 - 7883 |
|
~%
JNJ-28312141 CAS#:885692-52-4 |
| Literature: Illig, Carl R.; Manthey, Carl L.; Wall, Mark J.; Meegalla, Sanath K.; Chen, Jinsheng; Wilson, Kenneth J.; Ballentine, Shelley K.; Desjarlais, Renee L.; Schubert, Carsten; Crysler, Carl S.; Chen, Yanmin; Molloy, Christopher J.; Chaikin, Margery A.; Donatelli, Robert R.; Yurkow, Edward; Zhou, Zhao; Player, Mark R.; Tomczuk, Bruce E. Journal of Medicinal Chemistry, 2011 , vol. 54, # 22 p. 7860 - 7883 |
![1-Piperidinecarboxylic acid, 4-[4-amino-3-(1-cyclohexen-1-yl)phenyl]-, 1,1-dimethylethyl ester structure](https://image.chemsrc.com/caspic/280/885693-01-6.png)
![(4-{[4-cyano-1-(2-trimethylsilanylethoxymethyl)-1H-imidazole-2-carbonyl]amino}-3-cyclohex-1-enylphenyl)piperidine-1-carboxylic acid tert-butyl ester structure](https://image.chemsrc.com/caspic/242/885693-02-7.png)
| 4-cyano-1H-imidazole-2-carboxylic acid {2-cyclohex-1-enyl-4-[1-(2-dimethylaminoacetyl)piperidin-4-yl]phenyl}amide |
| 1H-Imidazole-2-carboxamide,5-cyano-n-(2-(1-cyclohexen-1-yl)-4-(1-(2-(dimethylamino)acetyl)-4-piperidinyl)phenyl) |
| UNII-YKQ241VJ92 |
| 1H-Imidazole-2-carboxamide, 4-cyano-N-[2-(1-cyclohexen-1-yl)-4-[1-[2-(dimethylamino)acetyl]-4-piperidinyl]phenyl]- |
| 4-Cyano-N-{2-(1-cyclohexen-1-yl)-4-[1-(N,N-dimethylglycyl)-4-piperidinyl]phenyl}-1H-imidazole-2-carboxamide |