Polyethylene-polypropylene glycol

Modify Date: 2024-01-01 20:21:25

Polyethylene-polypropylene glycol structure	Common Name	Polyethylene-polypropylene glycol
	CAS Number	9003-11-6	Molecular Weight	304.293
	Density	1.2±0.1 g/cm3	Boiling Point	370.7±37.0 °C at 760 mmHg
	Molecular Formula	C₁₃H₂₀O₈	Melting Point	60-50ºC
	MSDS	Chinese USA	Flash Point	160.5±26.5 °C

Use of Polyethylene-polypropylene glycol

Poloxamer 407 is a nonionic surfactant that is 100% active and relatively non-toxic to cells at low concentrations, and frequently used with dye AM esters such as Indo-1 AM, Fura-2 AM, Calcein AM, Fluo-3 AM, Fluo-4 AM, Quest Fluo-8™ AM and Quest Rhod-4™ AM, etc. to improve their water solubility.

Name	Polyethylene-polypropylene glycol
Synonym	More Synonyms

Description	Poloxamer 407 is a nonionic surfactant that is 100% active and relatively non-toxic to cells at low concentrations, and frequently used with dye AM esters such as Indo-1 AM, Fura-2 AM, Calcein AM, Fluo-3 AM, Fluo-4 AM, Quest Fluo-8™ AM and Quest Rhod-4™ AM, etc. to improve their water solubility.
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs). 1. Dissolve 1 g of Poloxamer 407 in 10 mL distilled water to make a 10% (w/v) stock solution, or 2 g of Poloxamer 407 in 10 mL DMSO to make a 20% (w/v) stock solution. These may require heating from 40 to 50°C for about 30 minutes. Store solution at room temperature. Do not refrigerate or freeze the Poloxamer 407 solution since it may precipitate. If precipitation is observed, the precipitates can be dissolved by heating to 37°C and vortexing before use. 2. Dilute the 10% or 20% Poloxamer 407 stock solution into the cell-loading buffer such as Hanks and 20 mM Hepes buffer (HHBS) at 1:1000 to 1:500 dilution to achieve a 0.02 to 0.04% working solution. 3. The DMSO stock solution of AM ester is then diluted into the 0.02 to 0.04% working solution to achieve a final AM ester concentration between 1 μM and 10 μM. The final concentration of Poloxamer 407 is normally kept at or below 0.08%. 4. The cells are incubated at a desired temperature for between 10 minutes and 1 hour. In general it is desirable to use the minimum amount of AM ester needed to achieve adequate fluorescence signal to noise levels. 5. After labeling, the cells are washed with HHBS or fresh medium before starting the experiment.
References	[1]. Antunes FE, et al. Gels of Pluronic F127 and nonionic surfactants from rheological characterization to controlled drug permeation. Colloids Surf B Biointerfaces. 2011 Oct 1;87(1):42-8.

Density	1.2±0.1 g/cm3
Boiling Point	370.7±37.0 °C at 760 mmHg
Melting Point	60-50ºC
Molecular Formula	C₁₃H₂₀O₈
Molecular Weight	304.293
Flash Point	160.5±26.5 °C
Exact Mass	304.115814
PSA	25.06000
LogP	0.00
Vapour density	>1 (vs air)
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.452
Storage condition	2-8°C
Water Solubility	H2O: at <70 °Csoluble

Polyethylene-polypropylene glycol MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TP6000000

CHEMICAL NAME :: Pluronic F98

CAS REGISTRY NUMBER :: 9003-11-6

LAST UPDATED :: 199710

DATA ITEMS CITED :: 7

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 175 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MIVRA6 Microvascular Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1968- Volume(issue)/page/year: 8,320,1974 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M3966 No. of Facilities: 6846 (estimated) No. of Industries: 44 No. of Occupations: 37 No. of Employees: 38016 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7313 No. of Facilities: 59555 (estimated) No. of Industries: 299 No. of Occupations: 176 No. of Employees: 1005983 (estimated) No. of Female Employees: 296376 (estimated)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	T
Risk Phrases	21-23/24/25-25-36/37/38
Safety Phrases	23-24/25-45-36/37/39-26
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	TP6164333
HS Code	39059100

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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Polyethylene-polypropylene glycol
Price: ￥448.0/500g ￥148.0/100g ￥528.0/500g ￥448.0/500g
Purity: 98.0%
Delivery: 3 Day
Contact: Liu jia
Email: 2130147988@qq.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: Poloxamer 188
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: Poloxamer 188
Price:
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Poloxamer
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Polyethylene-polypropylene glycol
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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