catechol o-methyltransferase

Modify Date: 2024-01-03 08:42:54

catechol o-methyltransferase Structure
catechol o-methyltransferase structure
Common Name catechol o-methyltransferase
CAS Number 9012-25-3 Molecular Weight 636.942
Density 1.0±0.1 g/cm3 Boiling Point 771.4±40.0 °C at 760 mmHg
Molecular Formula C38H68O7 Melting Point N/A
MSDS USA Flash Point 227.5±20.8 °C

 Use of catechol o-methyltransferase


Catechol O-methyltransferase (COMT) the magnesium-dependent transfer of methyl groups from S-adenosyl methionine to a hydroxyl group on dopamine, converting it to 3-methoxytyramine. Catechol O-methyltransferase has two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). Catechol O-methyltransferase is to regulate epinephrine, norepinephrine, and dopamine levels in the brain[1].

 Names

Name Catechol O-methyltransferases
Synonym More Synonyms

 catechol o-methyltransferase Biological Activity

Description Catechol O-methyltransferase (COMT) the magnesium-dependent transfer of methyl groups from S-adenosyl methionine to a hydroxyl group on dopamine, converting it to 3-methoxytyramine. Catechol O-methyltransferase has two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). Catechol O-methyltransferase is to regulate epinephrine, norepinephrine, and dopamine levels in the brain[1].
Related Catalog
References

[1]. Du X, et, al. A catechol-O-methyltransferase that is essential for auditory function in mice and humans. Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14609-14.  

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 771.4±40.0 °C at 760 mmHg
Molecular Formula C38H68O7
Molecular Weight 636.942
Flash Point 227.5±20.8 °C
Exact Mass 636.496521
LogP 7.50
Appearance of Characters lyophilized powder
Vapour Pressure 0.0±6.0 mmHg at 25°C
Index of Refraction 1.507
Storage condition −20°C

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
WGK Germany 3

 Articles75

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Complete sequencing and characterization of 21,243 full-length human cDNAs.

Nat. Genet. 36 , 40-5, (2004)

As a base for human transcriptome and functional genomics, we created the "full-length long Japan" (FLJ) collection of sequenced human cDNAs. We determined the entire sequence of 21,243 selected clone...

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Genome Res. 14 , 2121-7, (2004)

The National Institutes of Health's Mammalian Gene Collection (MGC) project was designed to generate and sequence a publicly accessible cDNA resource containing a complete open reading frame (ORF) for...

 Synonyms

MFCD00081488
2(5H)-Furanone, 3-[13-[5'-(1,5-dihydroxyundecyl)octahydro[2,2'-bifuran]-5-yl]-13-hydroxy-3-methyltridecyl]-5-methyl-
EINECS 232-727-6
3-{13-[5'-(1,5-Dihydroxyundecyl)octahydro-2,2'-bifuran-5-yl]-13-hydroxy-3-methyltridecyl}-5-methyl-2(5H)-furanone
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