Polymethylene polyphenyl polyisocyanate

Modify Date: 2024-01-02 15:43:37

Polymethylene polyphenyl polyisocyanate Structure
Polymethylene polyphenyl polyisocyanate structure
Common Name Polymethylene polyphenyl polyisocyanate
CAS Number 9016-87-9 Molecular Weight 250.252
Density 1.1±0.1 g/cm3 Boiling Point 373.4±35.0 °C at 760 mmHg
Molecular Formula C15H10N2O2 Melting Point N/A
MSDS Chinese USA Flash Point 154.0±31.3 °C
Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Danger

 Names

Name 1,1'-Methylenebis(4-isocyanatobenzene)
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 373.4±35.0 °C at 760 mmHg
Molecular Formula C15H10N2O2
Molecular Weight 250.252
Flash Point 154.0±31.3 °C
Exact Mass 250.074234
PSA 58.86000
LogP 4.93
Vapour density 8.6 (vs air)
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.588
Stability Stable. Incompatible with strong oxidizing agents, alcohols. May decompose in moist air, or on contact with water.

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TR0350000
CHEMICAL NAME :
Polymethylenepolyphenyl isocyanate
CAS REGISTRY NUMBER :
9016-87-9
LAST UPDATED :
199710

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0516728 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
49 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0516728
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
490 mg/m3/4H
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified Lungs, Thorax, or Respiration - respiratory depression Blood - hemorrhage
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555284
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>9400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460) Volume(issue)/page/year: OTS0517028 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
15 mg/m3/2W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - changes in lung weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0525557
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
12 mg/m3/13W-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0525557 ** TUMORIGENIC DATA **
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6 mg/m3/6H/2Y-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0525557 *** REVIEWS *** IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 19,303,1979 IARC Cancer Review:Animal No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 19,303,1979 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84716 No. of Facilities: 367 (estimated) No. of Industries: 10 No. of Occupations: 14 No. of Employees: 2795 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84716 No. of Facilities: 2951 (estimated) No. of Industries: 59 No. of Occupations: 48 No. of Employees: 45703 (estimated) No. of Female Employees: 6250 (estimated)

 Safety Information

Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Danger
Hazard Statements H315-H317-H319-H332-H334-H335-H351-H373
Precautionary Statements P260-P280-P284-P304 + P340-P305 + P351 + P338-P342 + P311
Hazard Codes Xn: Harmful;
Risk Phrases R20
Safety Phrases S26;S28;S38;S45
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS TR0350000
Packaging Group II
Hazard Class 6.1
HS Code 3909301000

 Customs

HS Code 3909301000

 Articles7

More Articles
Prevalence of occupational asthma in spray painters exposed to several types of isocyanates, including polymethylene polyphenylisocyanate.

J. Occup. Med. 29(4) , 340-4, (1987)

The prevalence of occupational asthma was assessed in four paint shops of a large assembly plant where 51 employees were exposed to several types of isocyanates, including polymethylene polyphenylisoc...

Toxicology, industrial hygiene and medical control of TDI, MDI and PMPPI.

Am. Ind. Hyg. Assoc. J. 43(2) , 89-97, (1982)

This presentation is authored particularly for those who demand comprehensive information regarding physiologic effects, toxicity, industrial hygiene and medical control of those isocyanates generally...

Mechanical properties of polyurethane foams prepared from liquefied corn stover with PAPI.

Bioresour. Technol. 99(7) , 2265-8, (2008)

Corn stover was liquefied by using ethylene carbonate (EC) as liquefying solvent and 97% sulfur acid as catalyst at 170 degrees C for 90 min. Polyurethane (PU) foams were prepared from liquefied corn ...

 Synonyms

N,N'''-1,6-Hexanediylbis(N'-cyanoguanidine),hexamethylenediamine polymer,hydrochloride
4,4′-Methylenebis(phenyl isocyanate)
4,4'-Methylenediphenyl diisocyanate
4,4'-Methylenebis(phenyl isocyanate)
diphenylmethane-4,4'-diisocyanate
Poly(hexamethylenebicyanoguanide-hexamethylenediamine) hydrochloride
PMDI
bis(4-isocyanatophenyl)methane
1,1'-methanediylbis(4-isocyanatobenzene)
polymeric diisocyanatodiphenylmethane
MFCD00072953
4,4'-Diphenylmethane diisocyanate
2,2'-hexane-1,6-diylbis(1-cyanoguanidine)-hexane-1,6-diamine hydrochloride(1:1:1)
1,1'-Methylenebis(4-isocyanatobenzene)
4,4'-MDI
polymeric biguanidin hydrochloride
1,6-Hexanediamine,polymer with N,N'''-1,6-hexanediylbis(N'-cyanoguanidine),hydrochloride
4,4'-Methylenediphenyl isocyanate
4,4'-Diisocyanatodiphenylmethane
4,4'-methylene bisphenyl diisocyanate
Benzene, 1,1'-methylenebis[4-isocyanato-
Methylene diphenyl diisocyanate
Polymethylene polyphenyl polyisocyanate
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