α-galactosidase

Modify Date: 2024-01-06 16:32:42

α-galactosidase Structure
α-galactosidase structure
Common Name α-galactosidase
CAS Number 9025-35-8 Molecular Weight 192.602
Density 1.4±0.1 g/cm3 Boiling Point 324.4±22.0 °C at 760 mmHg
Molecular Formula C9H5ClN2O Melting Point N/A
MSDS N/A Flash Point 150.0±22.3 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of α-galactosidase


α-Galactosidase (EC 3.2.1.22), that is, α-galactosidase, is a glycoside hydrolase that widely exists in animals, plants and microorganisms, and is often used in biochemical research. α-Galactosidase catalyzes the hydrolysis of α-1,6-linked terminal galactose residues, including galactooligosaccharides, galactomannans, and galactolipids. Catalyzes many catabolic processes including cleavage of glycoproteins, glycolipids and polysaccharides[1].

 Names

Name alpha-Galactosidase
Synonym More Synonyms

 α-galactosidase Biological Activity

Description α-Galactosidase (EC 3.2.1.22), that is, α-galactosidase, is a glycoside hydrolase that widely exists in animals, plants and microorganisms, and is often used in biochemical research. α-Galactosidase catalyzes the hydrolysis of α-1,6-linked terminal galactose residues, including galactooligosaccharides, galactomannans, and galactolipids. Catalyzes many catabolic processes including cleavage of glycoproteins, glycolipids and polysaccharides[1].
Related Catalog
References

[1]. Sonu Bhatia, et al. Microbial production and biotechnological applications of α-galactosidase. Int J Biol Macromol. 2020 May 1;150:1294-1313.   

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 324.4±22.0 °C at 760 mmHg
Molecular Formula C9H5ClN2O
Molecular Weight 192.602
Flash Point 150.0±22.3 °C
Exact Mass 192.009033
LogP 2.12
Appearance of Characters buffered aqueous solution
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.663
Storage condition 2-8°C

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Hazard Codes Xi
Risk Phrases 36/37/38
Safety Phrases 36/37-26
RIDADR NONH for all modes of transport
WGK Germany 3

 Articles56

More Articles
High throughput screening for inhibitors of alpha-galactosidase.

Curr. Chem. Genomics 4 , 67-73, (2011)

Fabry disease is a rare X-linked lysosomal storage disorder caused by a deficiency in α-galactosidase A (GLA), which catalyzes the hydrolysis of terminal α-galactosyl groups from glycosphingolipids, s...

Endothelial nitric oxide synthase uncoupling and microvascular dysfunction in the mesentery of mice deficient in α-galactosidase A.

Am. J. Physiol. Gastrointest. Liver Physiol. 306(2) , G140-6, (2014)

A defect in the gene for the lysosomal enzyme α-galactosidase A (Gla) results in globotriaosylceramide (Gb3) accumulation in Fabry disease and leads to premature death from cardiac and cerebrovascular...

Long-term effect of antibodies against infused alpha-galactosidase A in Fabry disease on plasma and urinary (lyso)Gb3 reduction and treatment outcome.

PLoS ONE 7(10) , e47805, (2012)

Enzyme replacement therapy (ERT) with alpha-Galactosidase A (aGal A) may cause antibody (AB) formation against aGal A in males with Fabry disease (FD). Anti agalsidase ABs negatively influence globotr...

 Synonyms

Agalsidase
E.C. 3.2.1.22
alpha-Galactoside galactohydrolase
Melibiase
2-Quinoxalinecarbonyl chloride
quinoxaline-2-carbonyl chloride
alpha-D-Galactosidase
alpha-GAL 600L
alpha-D-Galactopyranosidase
Alpha-Gal 1000
Validase AGS
alpha-D-Galactoside galactohydrolase
Alpha Gal 500
alpha-Galactosidase A
Sumizyme AGS
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