3,3'-Dichlorobenzidine

Modify Date: 2024-01-06 06:48:42

3,3'-Dichlorobenzidine Structure
3,3'-Dichlorobenzidine structure
 Common Name 3,3'-Dichlorobenzidine
CAS Number 91-94-1 Molecular Weight 253.127
Density 1.4±0.1 g/cm3 Boiling Point 385.0±37.0 °C at 760 mmHg
Molecular Formula C12H10Cl2N2 Melting Point 133ºC
MSDS Chinese USA Flash Point 186.6±26.5 °C
Symbol GHS02 GHS06 GHS08 GHS09
GHS02, GHS06, GHS08, GHS09		 Signal Word Danger

 Names

Name 3,3'-Dichlorobenzidine
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 385.0±37.0 °C at 760 mmHg
Melting Point 133ºC
Molecular Formula C12H10Cl2N2
Molecular Weight 253.127
Flash Point 186.6±26.5 °C
Exact Mass 252.022110
PSA 52.04000
LogP 3.45
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.679
Stability Stable. Incompatible with strong oxidizing agents.

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DD0525000
CHEMICAL NAME :
Benzidine, 3,3'-dichloro-
CAS REGISTRY NUMBER :
91-94-1
BEILSTEIN REFERENCE NO. :
2108022
LAST UPDATED :
199712
DATA ITEMS CITED :
53
MOLECULAR FORMULA :
C12-H10-Cl2-N2
MOLECULAR WEIGHT :
253.14
WISWESSER LINE NOTATION :
ZR BG DR DZ CG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
17 gm/kg/50W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Blood - tumors Skin and Appendages - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3600 mg/kg/61W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - breast
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5100 mg/kg/43W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
320 mg/kg female 15-21 day(s) after conception
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Reproductive - Tumorigenic effects - transplacental tumorigenesis Lungs, Thorax, or Respiration - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5200 mg/kg/47W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Tumorigenic - tumors at site of application
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
17 gm/kg/7Y-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
176 gm/kg/70W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
20 gm/kg/52W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors Skin and Appendages - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
21 gm/kg/50W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Blood - tumors Skin and Appendages - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7 gm/kg/43W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application
TYPE OF TEST :
Micronucleus test
TYPE OF TEST :
Mutation test systems - not otherwise specified
TYPE OF TEST :
Cytogenetic analysis

MUTATION DATA

TYPE OF TEST :
DNA adduct
TEST SYSTEM :
Mammal - species unspecified Lymphocyte
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 38,369,1982 *** REVIEWS *** ACGIH TLV-Animal carcinogen, NO TWA (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 4,49,1974 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 29,239,1982 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 29,239,1982 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,193,1987 TOXICOLOGY REVIEW ADCSAJ Advances in Chemistry Series. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) No.1- 1950- Volume(issue)/page/year: 13,271,1970 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD:skin-HUMAN CARCINOGEN, NO ASSIGNED TWA DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,77,1971 OSHA PEL (Gen Indu):see CFR 29,1910.1007 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):see CFR 29,1926.1107 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):see CFR 29,1915.1007 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA-cancer suspect agent CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1007,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA;Skin;Carcinogen JAN 1993 OEL-FRANCE;Carcinogen JAN 1993 OEL-GERMANY;Skin;Carcinogen JAN 1993 OEL-SWEDEN;Carcinogen JAN 1993 OEL-SWITZERLAND:TWA 0.1 mg/m3;Skin;Carcinogen JAN 1993 OEL-SWITZERLAND;Carcinogen JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO 3,3'-DICHLOROBENZIDINE-air:CA use 29 CFR 1910.1007 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992

 Safety Information

Symbol GHS02 GHS06 GHS08 GHS09
GHS02, GHS06, GHS08, GHS09
Signal Word Danger
Hazard Statements H225-H301 + H311 + H331-H350-H370-H411
Precautionary Statements P201-P210-P260-P273-P280-P301 + P310
Personal Protective Equipment Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes T,N,F
Risk Phrases R45
Safety Phrases S53-S45-S60-S61-S36/37-S16-S7
RIDADR UN 3077 9/PG 3
WGK Germany 3
RTECS DD0550000
Packaging Group II
Hazard Class 6.1
HS Code 2921590032

 Synthetic Route

Sodium hydroxide structure

Sodium hydroxide

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2',4'-Dimethylacetoacetanilide structure

2',4'-Dimethyla...

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N-(4-Chloro-2,5-dimethoxyphenyl)-3-oxobutanamide structure

N-(4-Chloro-2,5...

CAS#:4433-79-8

~%

3,3'-Dichlorobenzidine Structure

3,3'-Dichlorobe...

CAS#:91-94-1
Literature: US5420315 A1, ;
N,N'-DIACETYLBENZIDINE structure

N,N'-DIACETYLBE...

CAS#:613-35-4

~%

3,3'-Dichlorobenzidine Structure

3,3'-Dichlorobe...

CAS#:91-94-1
Literature: DE94410 ;
2-Nitrochlorobenzene structure

2-Nitrochlorobenzene

CAS#:88-73-3

~%

3,3'-Dichlorobenzidine Structure

3,3'-Dichlorobe...

CAS#:91-94-1
Literature: Chemische Berichte, , vol. 33, p. 3552
bis(2-chlorophenyl)diazene structure

bis(2-chlorophe...

CAS#:7334-33-0

~%

3,3'-Dichlorobenzidine Structure

3,3'-Dichlorobe...

CAS#:91-94-1
Literature: Journal of the Indian Chemical Society, , vol. 66, # 12 p. 865 - 867
Hydrochloric acid structure

Hydrochloric acid

CAS#:7647-01-0
1,2-Bis(2-chlorophenyl)hydrazine structure

1,2-Bis(2-chlor...

CAS#:782-74-1

~%

3,3'-Dichlorobenzidine Structure

3,3'-Dichlorobe...

CAS#:91-94-1
Literature: Chemische Berichte, , vol. 33, p. 3552
bis(2-chlorophenyl)diazene structure

bis(2-chlorophe...

CAS#:7334-33-0

~%

3,3'-Dichlorobenzidine Structure

3,3'-Dichlorobe...

CAS#:91-94-1

2-Chloroaniline structure

2-Chloroaniline

CAS#:95-51-2
Literature: Journal fuer Praktische Chemie (Leipzig), , vol. <2> 67, p. 152,153,163 Journal fuer Praktische Chemie (Leipzig), , vol. <2> 68, p. 208
Hydrochloric acid structure

Hydrochloric acid

CAS#:7647-01-0
Ethanol structure

Ethanol

CAS#:64-17-5
bis(2-chlorophenyl)diazene structure

bis(2-chlorophe...

CAS#:7334-33-0

~%

3,3'-Dichlorobenzidine Structure

3,3'-Dichlorobe...

CAS#:91-94-1

Detail
Literature: Zhurnal Obshchei Khimii, , vol. 7, p. 2209,2219, 2220 Chem. Zentralbl., , vol. 109, # I p. 3329 Zhurnal Obshchei Khimii, , vol. 6, p. 1064,1070 Chem. Zentralbl., , vol. 108, # I p. 2584

 Customs

HS Code 2921590032
Summary HS:2921590032 3,3'-dichloro-[1,1'-biphenyl]-4,4'-diamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:x MFN tariff:6.5% General tariff:30.0%

 Articles26

More Articles
Evidence that 4-aminobiphenyl, benzidine, and benzidine congeners produce genotoxicity through reactive oxygen species.

Environ. Mol. Mutagen. 48(5) , 404-13, (2007)

4-Aminobyphenyl (4-Ab), benzidine (Bz), and Bz congeners were evaluated for their ability to induce genotoxicity through an oxidative mechanism. The mutagenicity of these compounds was tested in the p...
Photodechlorination of 3,3'-dichlorobenzidine in water.

Environ. Toxicol. Chem. 21(3) , 500-6, (2002)

Laboratory experiments have been conducted to elucidate the photochemical behavior of 3,3'-dichlorobenzidine (DCB) and its congeners in aquatic systems. Photodechlorination of DCB was observed in aque...
Determination of dichlorobenzidine-hemoglobin adducts by GC/MS-NCI.

Int. Arch. Occup. Environ. Health 69(4) , 240-6, (1997)

A method based on gas chromatography/mass spectrometry-negative ion chemical ionization detection (GC/MS-NCI) was developed for the determination of 3,3'-dichlorobenzidine (DCB)-hemoglobin adducts. Ad...

 Synonyms

DCB
ortho,ortho'-Dichlorobenzidine
Dichlorobenzidine, 3,3'-
3,3'-Dichlorobenzidine
3,3'-Dichloro-4,4'-diamino(1,1-biphenyl)
3,3'-Dichloro-4,4'-biphenyldiamine
[1,1'-Biphenyl]-4,4'-diamine, 3,3'-dichloro-
3,3'-Dichloro-(1,1'-biphenyl)-4,4'-diamine
4-13-00-00384 (Beilstein Handbook Reference)
3,3`-dichlorobenzidine
3,3-Dichloro-(1,1'-biphenyl)-4,4'-diamine
MFCD00043917
4-(4-amino-3-chlorophenyl)-2-chloroaniline
EINECS 202-109-0
3,3'-Dichlorobiphenyl-4,4'-diamine
o,o'-dichlorobenzidine
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