Shield-1

Modify Date: 2024-01-05 10:45:20

Shield-1 Structure
Shield-1 structure
Common Name Shield-1
CAS Number 914805-33-7 Molecular Weight 748.90
Density N/A Boiling Point N/A
Molecular Formula C42H56N2O10 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Shield-1


Shield-1 is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused proteins. Shield-1 can stabilize the entire fusion protein[1][2].

 Names

Name Shield-1

 Shield-1 Biological Activity

Description Shield-1 is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused proteins. Shield-1 can stabilize the entire fusion protein[1][2].
Related Catalog
References

[1]. Schoeber JP, et al. Conditional fast expression and function of multimeric TRPV5 channels using Shield-1. Am J Physiol Renal Physiol. 2009 Jan;296(1):F204-11.

[2]. Li S, et al. Effects of Shield1 on the viral replication of varicella zoster virus containing FKBP tagged ORF4and 48. Mol Med Rep. 2018 Jan;17(1):763-770.

 Chemical & Physical Properties

Molecular Formula C42H56N2O10
Molecular Weight 748.90
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