Pyridine, 4-[5-[[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]thio]-1,3,4-oxadiazol-2-yl]

Modify Date: 2024-01-21 10:44:21

Pyridine, 4-[5-[[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]thio]-1,3,4-oxadiazol-2-yl] structure	Common Name	Pyridine, 4-[5-[[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]thio]-1,3,4-oxadiazol-2-yl]
	CAS Number	919936-70-2	Molecular Weight	337.35600
	Density	1.47±0.1 g/cm3 (20 °C, 760 mmHg)	Boiling Point	572.5±60.0 °C (760 mmHg)
	Molecular Formula	C₁₆H₁₁N₅O₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Pyridine, 4-[5-[[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]thio]-1,3,4-oxadiazol-2-yl]

GS87 is a highly specific and potent GSK3 inhibitor with IC50s of 415nM and 521nM for GSK3α and GSK3β, respectively. GS87 induces differentiation of acute myeloid leukemia (AML) cell lines by effectively activating GSK3-dependent signaling components including MAPK signaling. GS87 modulates key GSK3 target proteins involved in cell proliferation and differentiation more effectively than Lithium and SB415285 (SB). GS87 has the potential for acting as a differentiation agent for non-promyelocytic AML research[1].

Name	Pyridine, 4-[5-[[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]thio]-1,3,4-oxadiazol-2-yl]
Synonym	More Synonyms

Description	GS87 is a highly specific and potent GSK3 inhibitor with IC50s of 415nM and 521nM for GSK3α and GSK3β, respectively. GS87 induces differentiation of acute myeloid leukemia (AML) cell lines by effectively activating GSK3-dependent signaling components including MAPK signaling. GS87 modulates key GSK3 target proteins involved in cell proliferation and differentiation more effectively than Lithium and SB415285 (SB). GS87 has the potential for acting as a differentiation agent for non-promyelocytic AML research[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> GSK-3 Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3
Target	GSK3α:415 nM (IC50) GSK3β:521 nM (IC50)
References	[1]. Sophia Hu, et al. A Novel Glycogen Synthase Kinase-3 Inhibitor Optimized for Acute Myeloid Leukemia Differentiation Activity. Mol Cancer Ther. 2016 Jul;15(7):1485-1494.

Density	1.47±0.1 g/cm3 (20 °C, 760 mmHg)
Boiling Point	572.5±60.0 °C (760 mmHg)
Molecular Formula	C₁₆H₁₁N₅O₂S
Molecular Weight	337.35600
Exact Mass	337.06300
PSA	116.03000
LogP	3.47390

4-(5-([(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]sulfanyl)-1,3,4-oxadiazol-2-yl)pyridine

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Pyridine, 4-[5-[[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]thio]-1,3,4-oxadiazol-2-yl]

Use of Pyridine, 4-[5-[[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]thio]-1,3,4-oxadiazol-2-yl]

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