NGI-1 derivative C-19

Modify Date: 2024-01-17 01:32:52

NGI-1 derivative C-19 Structure
NGI-1 derivative C-19 structure
 Common Name NGI-1 derivative C-19
CAS Number 924471-88-5 Molecular Weight 415.508
Density N/A Boiling Point N/A
Molecular Formula C21H25N3O4S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of NGI-1 derivative C-19


NGI-1 derivative C-19 is a specific, small-molecule inhibitor of oligosaccharyltransferase (OST) catalytic subunit STT3B, without effect on STT3A; reduces ligand stimulated activation of EGFR, in STT3A-ko cells, where EGFR glycosylation is dependent on STT3B alone, does not reduce glycosylation and ligand stimulation of EGFR in parental and STT3B-ko cells; NGI-1 derivative C-19 has discrete biological effects on endogenous STT3B target proteins such as COX2 but does not activate the cellular unfolded protein response (UPR).

 Names

Name NGI-1 derivative C-19

 NGI-1 derivative C-19 Biological Activity

Description NGI-1 derivative C-19 is a specific, small-molecule inhibitor of oligosaccharyltransferase (OST) catalytic subunit STT3B, without effect on STT3A; reduces ligand stimulated activation of EGFR, in STT3A-ko cells, where EGFR glycosylation is dependent on STT3B alone, does not reduce glycosylation and ligand stimulation of EGFR in parental and STT3B-ko cells; NGI-1 derivative C-19 has discrete biological effects on endogenous STT3B target proteins such as COX2 but does not activate the cellular unfolded protein response (UPR).
References References 1. Rinis N, et al. Cell Chem Biol. 2018 Jul 24. pii: S2451-9456(18)30232-0. View Related Products by Target Other Targets

 Chemical & Physical Properties

Molecular Formula C21H25N3O4S
Molecular Weight 415.508
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Chemsrc provides NGI-1 derivative C-19(CAS#:924471-88-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of NGI-1 derivative C-19 are included as well.>> amp version: NGI-1 derivative C-19

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