MK-0952

Modify Date: 2024-01-08 18:55:12

MK-0952 structure	Common Name	MK-0952
	CAS Number	934995-87-6	Molecular Weight	483.49000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₈H₂₂FN₃O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of MK-0952

MK-0952 is a selective and orally active PDE4 inhibitor, with an IC50 of 0.53 nM. MK-0952 has the potential for Alzheimer’s disease study[1][2].

Name	(1R,2R)-2-{3'-[3-(Cyclopropylcarbamoyl)-4-oxo-1,8-naphthyridin-1( 4H)-yl]-3-fluoro-4-biphenylyl}cyclopropanecarboxylic acid

Description	MK-0952 is a selective and orally active PDE4 inhibitor, with an IC50 of 0.53 nM. MK-0952 has the potential for Alzheimer’s disease study[1][2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Neurological Disease
Target	PDE4:0.53 nM (IC50)
In Vivo	MK-0952 (10 mg/kg) induces malaise in the rat[1].
References	[1]. Michel Gallant, et al. Discovery of MK-0952, a Selective PDE4 Inhibitor for the Treatment of Long-Term Memory Loss and Mild Cognitive Impairment. Epub 2010 Sep 21. [2]. Tingting Pan, et al. Dual Functional Cholinesterase and PDE4D Inhibitors for the Treatment of Alzheimer's Disease: Design, Synthesis and Evaluation of tacrine-pyrazolo[3,4-b]pyridine Hybrids. Behav Brain Res. 2016 Apr 15;303:26-33.

Molecular Formula	C₂₈H₂₂FN₃O₄
Molecular Weight	483.49000
Exact Mass	483.15900
PSA	104.78000
LogP	4.84690

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: MK-0952
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

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