MK-7288

Modify Date: 2024-09-13 16:53:56

MK-7288 Structure
MK-7288 structure
Common Name MK-7288
CAS Number 936626-07-2 Molecular Weight 401.499
Density 1.2±0.1 g/cm3 Boiling Point 622.5±55.0 °C at 760 mmHg
Molecular Formula C22H31N3O4 Melting Point N/A
MSDS N/A Flash Point 330.2±31.5 °C

 Use of MK-7288


A novel histamine H3 receptor inverse agonist for the treatment of sleep apnoea syndrome; significantly prolongs MWT sleep latency, and improves car driving simulation standard deviation of lane position in clinical trials. Sleep Disorder Phase 1 Clinical

 Names

Name (1r,4r)-2'-Methoxy-N-methyl-7'-oxo-N-[2-(1-piperidinyl)ethyl]-7'H-spiro[cyclohexane-1,5'-furo[3,4-b]pyridine]-4-carboxamide
Synonym More Synonyms

 MK-7288 Biological Activity

Description A novel histamine H3 receptor inverse agonist for the treatment of sleep apnoea syndrome; significantly prolongs MWT sleep latency, and improves car driving simulation standard deviation of lane position in clinical trials. Sleep Disorder Phase 1 Clinical
References References 1. Sun H, et al. J Clin Pharmacol. 2013 Dec;53(12):1294-302. View Related Products by Target Histamine Receptor Sleep Disorder

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 622.5±55.0 °C at 760 mmHg
Molecular Formula C22H31N3O4
Molecular Weight 401.499
Flash Point 330.2±31.5 °C
Exact Mass 401.231445
LogP 1.73
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.587

 Synonyms

Spiro[cyclohexane-1,5'(7'H)-furo[3,4-b]pyridine]-4-carboxamide, 2'-methoxy-N-methyl-7'-oxo-N-[2-(1-piperidinyl)ethyl]-
(1r,4r)-2'-Methoxy-N-methyl-7'-oxo-N-[2-(1-piperidinyl)ethyl]-7'H-spiro[cyclohexane-1,5'-furo[3,4-b]pyridine]-4-carboxamide
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