p,p'-DDD-d8

Modify Date: 2024-01-05 15:10:16

p,p'-DDD-d8 Structure
p,p'-DDD-d8 structure
Common Name p,p'-DDD-d8
CAS Number 93952-20-6 Molecular Weight 328.09000
Density N/A Boiling Point N/A
Molecular Formula C14H2Cl4D8 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of p,p'-DDD-d8


p,p'-DDD-d8 is the deuterium labeled p,p'-DDD[1]. p,p'-DDD is a major metabolite of p,p'-DDT. p,p'-DDD occurs in the feces and livers of rats, that are given p,p'-DDT by stomach tube, but not of rats injected intraperitoneally with p,p'-DDT[2][3].

 Names

Name 4,4′-Dichlorobenzophenone D8

 p,p'-DDD-d8 Biological Activity

Description p,p'-DDD-d8 is the deuterium labeled p,p'-DDD[1]. p,p'-DDD is a major metabolite of p,p'-DDT. p,p'-DDD occurs in the feces and livers of rats, that are given p,p'-DDT by stomach tube, but not of rats injected intraperitoneally with p,p'-DDT[2][3].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Mendel JL, et al. Conversion of p,p' -DDT to p,p' -DDD by intestinal flora of the rat. Science. 1966;151(3717):1527-1528.  

[3]. Gerić M, et al. Cytogenetic status of human lymphocytes after exposure to low concentrations of p,p'-DDT, and its metabolites (p,p'-DDE, and p,p'-DDD) in vitro. Chemosphere. 201287(11):1288-1294.  

 Chemical & Physical Properties

Molecular Formula C14H2Cl4D8
Molecular Weight 328.09000
Exact Mass 326.00400
LogP 5.92900
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