P11
Modify Date: 2024-01-09 19:04:25
P11 structure
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Common Name | P11 | ||
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| CAS Number | 942285-55-4 | Molecular Weight | 503.652 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 667.0±65.0 °C at 760 mmHg | |
| Molecular Formula | C30H33NO4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 357.2±34.3 °C | |
Use of P11PAFAH inhibitor P11 (P11) is a potent, selective platelet-activating factor acetylhydrolases PAFAH1b2 and PAFAH1b3 inhibitor with IC50 of 40 nM and 900 nM respectively; blocks PAFAH1b2- and PAFAH1b3-mediated hydrolysis of the substrate PAF to lyso-PAF with IC50 values of 36 nM and 880 nM; impairs tumor cell survival; in situ-active and can be used to investigate the cellular functions of PAFAH1b2/3. |
| Name | (2S,6S)-6-(4-Methylphenyl)-1-[(4-methylphenyl)sulfonyl]-2-[4-(2-methyl-2-propanyl)phenyl]-1,2,5,6-tetrahydro-3-pyridinecarboxylic acid |
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| Synonym | More Synonyms |
| Description | PAFAH inhibitor P11 (P11) is a potent, selective platelet-activating factor acetylhydrolases PAFAH1b2 and PAFAH1b3 inhibitor with IC50 of 40 nM and 900 nM respectively; blocks PAFAH1b2- and PAFAH1b3-mediated hydrolysis of the substrate PAF to lyso-PAF with IC50 values of 36 nM and 880 nM; impairs tumor cell survival; in situ-active and can be used to investigate the cellular functions of PAFAH1b2/3. |
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| References | References 1. Chang JW, et al. ACS Chem Biol. 2015 Apr 17;10(4):925-32. View Related Products by Target Other Targets |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 667.0±65.0 °C at 760 mmHg |
| Molecular Formula | C30H33NO4S |
| Molecular Weight | 503.652 |
| Flash Point | 357.2±34.3 °C |
| Exact Mass | 503.213043 |
| LogP | 8.19 |
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
| Index of Refraction | 1.607 |
| (2S,6S)-6-(4-Methylphenyl)-1-[(4-methylphenyl)sulfonyl]-2-[4-(2-methyl-2-propanyl)phenyl]-1,2,5,6-tetrahydro-3-pyridinecarboxylic acid |
| 3-Pyridinecarboxylic acid, 2-[4-(1,1-dimethylethyl)phenyl]-1,2,5,6-tetrahydro-6-(4-methylphenyl)-1-[(4-methylphenyl)sulfonyl]-, (2S,6S)- |