3,4-Dichloroaniline

Modify Date: 2024-01-04 13:32:07

3,4-Dichloroaniline Structure
3,4-Dichloroaniline structure
Common Name 3,4-Dichloroaniline
CAS Number 95-76-1 Molecular Weight 162.017
Density 1.4±0.1 g/cm3 Boiling Point 271.8±20.0 °C at 760 mmHg
Molecular Formula C6H5Cl2N Melting Point 69-71 °C(lit.)
MSDS Chinese USA Flash Point 118.2±21.8 °C
Symbol GHS05 GHS06 GHS09
GHS05, GHS06, GHS09
Signal Word Danger

 Names

Name 3,4-dichloroaniline
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 271.8±20.0 °C at 760 mmHg
Melting Point 69-71 °C(lit.)
Molecular Formula C6H5Cl2N
Molecular Weight 162.017
Flash Point 118.2±21.8 °C
Exact Mass 160.979904
PSA 26.02000
LogP 2.51
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.614
Stability Stable, but darkens in storage. Combustible. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides.
Water Solubility 0.06 g/100 mL

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
BX2625000
CHEMICAL NAME :
Aniline, 3,4-dichloro-
CAS REGISTRY NUMBER :
95-76-1
BEILSTEIN REFERENCE NO. :
0636837
LAST UPDATED :
199710
DATA ITEMS CITED :
25
MOLECULAR FORMULA :
C6-H5-Cl2-N
MOLECULAR WEIGHT :
162.02
WISWESSER LINE NOTATION :
ZR CG DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
545 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
65 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
280 mg/kg
TOXIC EFFECTS :
Behavioral - excitement Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
740 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
310 mg/kg
TOXIC EFFECTS :
Behavioral - excitement Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
675 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
675 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - wild bird species
DOSE/DURATION :
237 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6370 mg/kg/13W-I
TOXIC EFFECTS :
Endocrine - changes in spleen weight Blood - changes in erythrocyte (RBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3640 mg/kg/26W-I
TOXIC EFFECTS :
Behavioral - alteration of classical conditioning Blood - methemoglobinemia-carboxyhemoglobin Blood - changes in erythrocyte (RBC) count
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
30 ug/m3/24H/14W-C
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Human Lymphocyte
DOSE/DURATION :
125 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 226,197,1989 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.5 mg/m3;Skin JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4030 No. of Facilities: 17 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 851 (estimated) No. of Female Employees: 187 (estimated)

 Safety Information

Symbol GHS05 GHS06 GHS09
GHS05, GHS06, GHS09
Signal Word Danger
Hazard Statements H301-H311-H317-H318-H331-H410
Precautionary Statements P261-P273-P280-P301 + P310-P305 + P351 + P338-P311
Personal Protective Equipment Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes T:Toxic
Risk Phrases R23/24/25;R41;R43;R50/53
Safety Phrases S26-S36/37/39-S45-S60-S61
RIDADR UN 3442 6.1/PG 2
WGK Germany 3
RTECS BX2625000
Packaging Group II
Hazard Class 6.1
HS Code 2921420090

 Synthetic Route

 Customs

HS Code 2921420090
Summary HS:2921420090 aniline derivatives and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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 Synonyms

3,4-DICHLORO ANILINE
ZR CG DG
3,4- DICHLORO ANILINE
3,4-dichloro-aniline
3,4-DICHLOROANILINE-D2
4-Amino-1,2-dichlorobenzene
Benzenamine,3,4-dichloro
EINECS 202-448-4
4,5-Dichloroaniline
3 4 DICHLORO ANILINE
3,4-dichlorophenylamine
3,4-DICHLOROANILINE FOR SYNTHESIS
Benzenamine, 3,4-dichloro-
Gefitinib Impurity III
3:4 DI CHLORO ANILINE
3,4-Dichloraniline
3,4-Dichloroaniline
MFCD00007768
3,4-DCA
3,4-DICHLOROANILINE D
3, 4-DICHLOROANILINE
3,4-Dichlorobenzenamine
1,2-Dichloro-4-aminobenzene
3,4-DICHLORANILIN
1-Amino-3,4-dichlorobenzene
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