AGN 196996

Modify Date: 2024-01-05 17:07:19

AGN 196996 Structure
AGN 196996 structure
Common Name AGN 196996
CAS Number 958295-17-5 Molecular Weight 482.32300
Density 1.453±0.06 g/cm3 (20 °C, 760 mmHg) Boiling Point 619.8±55.0 °C (760 mmHg)
Molecular Formula C24H20BrNO5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of AGN 196996


AGN 196996 is a potent and selective RARα antagonist with Ki value of 2 nM; little binding affinity for RARβ(Ki=1087 nM) and RARγ(Ki=8523 nM).IC50 value: 2 nM(Ki)Target: RARα antagonistAGN 196996 shows no activity in transactivation assays, but instead block the gene transcriptional activity induced by ATRA and other RAR agonists.

 Names

Name Benzoic acid, 4-[[3-bromo-4-ethoxy-5-(4-methylbenzoyl)benzoyl]amino]
Synonym More Synonyms

 AGN 196996 Biological Activity

Description AGN 196996 is a potent and selective RARα antagonist with Ki value of 2 nM; little binding affinity for RARβ(Ki=1087 nM) and RARγ(Ki=8523 nM).IC50 value: 2 nM(Ki)Target: RARα antagonistAGN 196996 shows no activity in transactivation assays, but instead block the gene transcriptional activity induced by ATRA and other RAR agonists.
Related Catalog
References

[1]. Hammond LA, et al. Antagonists of retinoic acid receptors (RARs) are potent growth inhibitors of prostate carcinoma cells. Br J Cancer. 2001 Aug 3;85(3):453-62.

[2]. Keedwell RG, et al. An antagonist of retinoic acid receptors more effectively inhibits growth of human prostate cancer cells than normal prostate epithelium. Br J Cancer. 2004 Aug 2;91(3):580-8.

 Chemical & Physical Properties

Density 1.453±0.06 g/cm3 (20 °C, 760 mmHg)
Boiling Point 619.8±55.0 °C (760 mmHg)
Molecular Formula C24H20BrNO5
Molecular Weight 482.32300
Exact Mass 481.05200
PSA 92.70000
LogP 5.41070
Storage condition 2-8℃

 Synonyms

AGN 196996
Top Suppliers:I want be here


Get all suppliers and price by the below link:

AGN 196996 suppliers


Price: $850/5mg

Reference only. check more AGN 196996 price