Ipsapirone
Modify Date: 2024-01-04 23:03:34
Ipsapirone structure
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Common Name | Ipsapirone | ||
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| CAS Number | 95847-70-4 | Molecular Weight | 401.48300 | |
| Density | 1.345g/cm3 | Boiling Point | 629.8ºC at 760mmHg | |
| Molecular Formula | C19H23N5O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 334.7ºC | |
Use of IpsapironeIpsapirone (TVX Q 7821), an anxiolytic compound and a 5-HT1A partial agonist, also exhibits 5-HT1A antagonistic effect, and only at high doses it can also produce an inhibitory effect on 5-HT2 and the α1-adrenergic function[1][2]. |
| Name | 1,1-dioxo-2-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-1,2-benzothiazol-3-one |
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| Synonym | More Synonyms |
| Description | Ipsapirone (TVX Q 7821), an anxiolytic compound and a 5-HT1A partial agonist, also exhibits 5-HT1A antagonistic effect, and only at high doses it can also produce an inhibitory effect on 5-HT2 and the α1-adrenergic function[1][2]. |
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| Related Catalog | |
| Target |
5-HT1A Receptor |
| In Vivo | Ipsapirone inhibits induced by 8-OH-DPAT and 5-methoxydimethyltryptamine (agonists of 5-HT1A receptors) behavioural effects (flat body posture and forepaw treading) in normal and reserpinized rats[1]. Ipsapirone (2.5-80 mg/kg), given alone to rats induces a slight flattening of body posture (~ 1 point at the highest dose) and a mild hind limb abduction observed at doses 2.5-80 mg/kg. Ipsapirone given alone at low doses (2.5-10 mg/kg i.p.) does not significantly change the body temperature in rats and mice, but decreased it in both those species at high doses (35 mg/kg i.p.) by ca. 2-2.5℃[1]. Animal Model: Male Albino-Swiss mice (18-24 g) and male Wistar rats (160-200 g)[1]. Dosage: 5 and 10 mg/kg. Administration: IP 30 min before 8-OH-DPAT and 5-MeODMT injections. Result: Behavioural responses (flat body posture, forepaw treading) to 8-OH-DPAT (5 mg/kg s.c.) in rats were antagonized by Ipsapirone (5 and 10 mg/kg i.p.). |
| References |
| Density | 1.345g/cm3 |
|---|---|
| Boiling Point | 629.8ºC at 760mmHg |
| Molecular Formula | C19H23N5O3S |
| Molecular Weight | 401.48300 |
| Flash Point | 334.7ºC |
| Exact Mass | 401.15200 |
| PSA | 95.09000 |
| LogP | 2.24510 |
| Index of Refraction | 1.622 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| ABT 702 dihydrochloride |
| Ipsapironum |
| IPSAPIRONE |
| Ipsapirona |