Streptolysin O
Streptolysin O structure
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Common Name | Streptolysin O | ||
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| CAS Number | 98072-47-0 | Molecular Weight | N/A | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | N/A | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of Streptolysin OStreptolysin O, a group A streptococcal toxin, is a well-characterized oxygen-labile prototype of a cholesterol-binding bacterial exotoxin. Streptolysin O causes both lysis of cells and cardiotoxicity. Streptolysin O is widely used for the controlled permeabilization of cell membranes. Streptolysin O exists in two forms, a reduced active state and an oxidized reversibly inactive state [1][2][3][4]. |
| Name | STREPTOLYSIN O |
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| Synonym | More Synonyms |
| Description | Streptolysin O, a group A streptococcal toxin, is a well-characterized oxygen-labile prototype of a cholesterol-binding bacterial exotoxin. Streptolysin O causes both lysis of cells and cardiotoxicity. Streptolysin O is widely used for the controlled permeabilization of cell membranes. Streptolysin O exists in two forms, a reduced active state and an oxidized reversibly inactive state [1][2][3][4]. |
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| Related Catalog | |
| In Vitro | When Streptolysin O is secreted by streptococci, it is in an active state, but it rapidly oxidizes to a reversibly inactive state with the formation of disulfide bonds[2]. Streptolysin O, belongs to the group of thiol-activated toxins, is a secreted virulence factor of GAS that induces apoptosis in neutrophils and macrophages at later time points (~4 h). Streptolysin O induces eukaryotic cell lysis in a cholesterol-dependent manner, is highly upregulated in the GAS M1T1 clone during bloodstream dissemination. Streptolysin O is known to promote Group A Streptococcus (GAS) resistance to phagocytic clearance by neutrophils, a critical first element of host defense against invasive bacterial infection[3]. |
| References |
| Appearance of Characters | lyophilized powder |
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| Storage condition | 2-8°C |
| Water Solubility | H2O: soluble1mg/mL |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | UN 2811PIH 6.1 / PGI |
| WGK Germany | 3 |
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Suicide cancer gene therapy using pore-forming toxin, streptolysin O.
Mol. Cancer Ther. 5 , 1610-1619, (2006) We cloned the streptolysin O gene from the Streptococcus pyogenes genome and tested the possibility of using it as an anticancer reagent. Transient transfection of the streptolysin O gene efficiently ... |
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Inhibition of streptolysin O by allicin - an active component of garlic.
J. Med. Microbiol. 59 , 1044-1049, (2010) Streptolysin O (SLO) is a potent cytolytic toxin produced by almost all strains of group A streptococci and is considered an important virulence factor for this organism. In this study we investigated... |
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Neurotransmitter interactions related to central dopamine neurons.
Essays Neurochem. Neuropharmacol. 3 , 129-207, (1978)
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| EINECS 308-500-3 |