m-phthaloyl chloride

Modify Date: 2024-01-02 17:08:56

m-phthaloyl chloride structure	Common Name	m-phthaloyl chloride
	CAS Number	99-63-8	Molecular Weight	203.022
	Density	1.4±0.1 g/cm3	Boiling Point	276.7±13.0 °C at 760 mmHg
	Molecular Formula	C₈H₄Cl₂O₂	Melting Point	43-44 °C(lit.)
	MSDS	Chinese USA	Flash Point	131.9±15.4 °C
	Symbol	GHS05, GHS06	Signal Word	Danger

Name	Isophthaloyl Chloride
Synonym	More Synonyms

Density	1.4±0.1 g/cm3
Boiling Point	276.7±13.0 °C at 760 mmHg
Melting Point	43-44 °C(lit.)
Molecular Formula	C₈H₄Cl₂O₂
Molecular Weight	203.022
Flash Point	131.9±15.4 °C
Exact Mass	201.958832
PSA	34.14000
LogP	2.48
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.571
Water Solubility	reacts

m-phthaloyl chloride MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NT2625000

CHEMICAL NAME :: Isophthaloyl chloride

CAS REGISTRY NUMBER :: 99-63-8

BEILSTEIN REFERENCE NO. :: 0638342

LAST UPDATED :: 199710

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C8-H4-Cl2-O2

MOLECULAR WEIGHT :: 203.02

WISWESSER LINE NOTATION :: GVR CVG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 11/3/1971

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 11/3/1971 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 Volume(issue)/page/year: -,475,1969

TYPE OF TEST :: LC - Lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >31 gm/m3/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0533736

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2221 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Behavioral - changes in motor activity (specific assay)

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 47(7),75,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1175 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Behavioral - changes in motor activity (specific assay)

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 47(7),75,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1410 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 28,313,1974 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1817 mg/kg/22W-I

TOXIC EFFECTS :: Blood - changes in leukocyte (WBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 47(7),75,1982

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 gm/kg/2W-I

TOXIC EFFECTS :: Gastrointestinal - alteration in gastric secretion Related to Chronic Data - death

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0533736 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4719 No. of Facilities: 23 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 45 (estimated)

Symbol	GHS05, GHS06
Signal Word	Danger
Hazard Statements	H312-H314-H331
Precautionary Statements	P261-P280-P305 + P351 + P338-P310
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	C:Corrosive
Risk Phrases	R34
Safety Phrases	S26-S36/37/39-S45-S7/8-S24/25
RIDADR	UN 3261 8/PG 2
WGK Germany	1
RTECS	NT2625000
Packaging Group	II
Hazard Class	8
HS Code	29173940

Precursor 10
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DownStream 10
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HS Code	2917399090
Summary	2917399090 aromatic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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EINECS 202-774-7

Isophthaloyl dichloride

1,3-Benzenedicarbonyl dichloride

MFCD00000678

benzene-1,3-dicarbonyl dichloride

isophthalic acid dichloride

m-phthaloyl chloride