ethyl 2,3,5,6-tetradeuterio-4-phenylpiperidine-4-carboxylate

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SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Highly flammable. Toxic by inhalation, in contact with skin and if
swallowed. Toxic: danger of very serious irreversible effects
through inhalation, in contact with skin and if swallowed.

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3 - Composition/Information on Ingredients

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Product NameCAS #EC noAnnex I
Index Number
NORMEPERIDINE (1MG/ML METHANOLNoneNoneNone
SOLN)
Ingredient NamePercent CAS #EC noAnnex I
Index Number
METHANOL99.967-56-1200-659-6 603-001-00-X
Symbols: F-T
R-Phrases: 11-23/24/25-39/23/24/25
Highly flammable. Toxic by inhalation, in contact with skin and if
swallowed. Toxic: danger of very serious irreversible effects
through inhalation, in contact with skin and if swallowed.
4-PHENYL-4-PIPERIDINECARB0.1NoneNoneNone
OXYLIC ACID ETHYL ESTER
Symbols: Xn
R-Phrases: 22
Harmful if swallowed.

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4 - First Aid Measures

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AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
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AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.

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5 - Fire Fighting Measures

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EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Flammable liquid. Emits toxic fumes under
fire conditions.
Explosion Hazards: Vapor may travel considerable distance to
source of ignition and flash back. Container explosion may occur
under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.

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6 - Accidental Release Measures

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PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
ENVIRONMENTAL PRECAUTION(S)
Do not allow material to enter drains or water courses. Avoid
contaminating sewers and waterways with this material.
METHODS FOR CLEANING UP
Cover with dry-lime, sand, or soda ash. Place in covered
containers using non-sparking tools and transport outdoors.
Ventilate area and wash spill site after material pickup is
complete.

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7 - Handling and Storage

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HANDLING
Directions for Safe Handling: Do not breathe vapor. Avoid
contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure. Do not use if skin is cut or scratched. Wash
thoroughly after handling.
STORAGE
Conditions of Storage: Keep tightly closed. Keep away from heat,
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sparks, and open flame.
Store at -20°C

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8 - Exposure Controls / Personal Protection

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ENGINEERING CONTROLS
Safety shower and eye bath. Use nonsparking tools. Use only in a
chemical fume hood.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling. Discard contaminated clothing and
shoes.
EXPOSURE LIMITS
CountrySourceTypeValue
PolandNDS100 MG/M3
PolandNDSCh300 MG/M3
PolandNDSP-
EXPOSURE LIMITS - DENMARK
SourceTypeValue
OELTWA260,0000 mg/m3
200,0000 ppm
Remarks: H, methanol
EXPOSURE LIMITS - GERMANY
SourceTypeValue
TRGS 900OEL260,0000 mg/m3
200,0000 ppm
Remarks: 4
Remarks: H, methanol
EXPOSURE LIMITS - NORWAY
SourceTypeValue
OELTWA130,0000 mg/m3
100,0000 ppm
Remarks: H, methanol
EXPOSURE LIMITS - SWEDEN
SourceTypeValue
LLV (Level250,0000 mg/m3
200,0000 ppm
Remarks: H
Remarks: methanol
EXPOSURE LIMITS - SWITZERLAND
SourceTypeValue
OEL OEL260,0000 mg/m3
200,0000 ppm
Remarks: H M C
Remarks: methanol
EXPOSURE LIMITS - UNITED KINGDOM
SourceTypeValue
OEL OEL266,0000 mg/m3
200,0000 ppm
Remarks: methanol
OELSTEL333,0000 mg/m3
250,0000 ppm
Remarks: Skin Indicative limit value
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Remarks: methanol
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Use respirators and components tested and
approved under appropriate government standards such as NIOSH (US)
or CEN (EU). Use supplied-air or SCBA respirators. Europe permits
the use of type AXBEK full-face cartridge respirators (EN 14387).
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.

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9 - Physical and Chemical Properties

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AppearancePhysical State: Liquid
PropertyValueAt Temperature or Pressure
pH N/A
BP/BP RangeN/A
MP/MP RangeN/A
Flash PointN/A
FlammabilityN/A
Autoignition TempN/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion LimitsN/A
Vapor PressureN/A
Partition Coefficient N/A
ViscosityN/A
Vapor DensityN/A
Saturated Vapor Conc. N/A
Evaporation RateN/A
Bulk DensityN/A
Decomposition Temp.N/A
Solvent ContentN/A
Water ContentN/A
Surface TensionN/A
ConductivityN/A
Miscellaneous DataN/A
SolubilityN/A

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10 - Stability and Reactivity

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STABILITY
Stable: Stable.
Materials to Avoid: Acids, Acid chlorides, Acid anhydrides,
Oxidizing agents, Alkali metals, Reducing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur

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11 - Toxicological Information

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SIGNS AND SYMPTOMS OF EXPOSURE
Nausea, headache, and vomiting. Gastrointestinal disturbances.
Dizziness. Weakness. Confusion. Drowsiness. Unconsciousness. To
the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
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Ingestion can cause: Methyl alcohol may be fatal or cause
blindness if swallowed. Cannot be made non-poisonous.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: Toxic if absorbed through skin.
Eye Contact: May cause eye irritation.
Inhalation: Material may be irritating to mucous membranes and
upper respiratory tract. Toxic if inhaled.
Ingestion: Toxic if swallowed.
TARGET ORGAN INFORMATION
Eyes. Kidneys. Liver. Heart.

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12 - Ecological Information

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No data available.

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13 - Disposal Considerations

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SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Burn in a chemical incinerator equipped with an
afterburner and scrubber but exert extra care in igniting as this
material is highly flammable. Observe all federal, state, and
local environmental regulations.

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14 - Transport Information

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RID/ADR
UN#: 1230
Class: 3
PG: II
Subrisk: 6.1
Proper Shipping Name: Methanol solution
IMDG
UN#: 1230
Class: 3
PG: II
Subrisk: 6.1
Proper Shipping Name: Methanol solution
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 1230
Class: 3
PG: II
Subrisk: 6.1
Proper Shipping Name: Methanol solution
Inhalation Packing Group I: No

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15 - Regulatory Information

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CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: F-T
Highly Flammable. Toxic.
R-PHRASES: 11-23/24/25-39/23/24/25
Highly flammable. Toxic by inhalation, in contact with skin and
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if swallowed. Toxic: danger of very serious irreversible
effects through inhalation, in contact with skin and if
swallowed.
S-PHRASES: 7-16-36/37-45
Keep container tightly closed. Keep away from sources of
ignition - no smoking. Wear suitable protective clothing and
gloves. In case of accident or if you feel unwell, seek medical
advice immediately (show the label where possible).
Caution: Substance not yet fully tested (EU).
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 1
Self-Classification

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16 - Other Information

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WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2010 Co. License granted to make
unlimitedpaper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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SECTION 16 - ADDITIONAL INFORMATION
N/A