FR-167356

Modify Date: 2024-01-26 08:26:30

FR-167356 Structure
FR-167356 structure
Common Name FR-167356
CAS Number 174185-16-1 Molecular Weight 378.24900
Density 1.385 g/cm3 Boiling Point 422.714ºC at 760 mmHg
Molecular Formula C19H17Cl2NO3 Melting Point N/A
MSDS N/A Flash Point 209.45ºC

 Use of FR-167356


FR-167356 is a potent, orally active and selective vacuolar ATPase inhibitor with IC50 values of 170, 220, 370, and 1200 nM for osteoclast plasma membranes, macrophage microsomes, renal brush border membranes, and liver lysosomal membranes, respectively. FR-167356 inhibits bone resorption and ovariectomy-induced bone loss[1].

 Names

Name 2,6-dichloro-N-[3-(2-hydroxypropan-2-yl)-2-methyl-1-benzofuran-7-yl]benzamide
Synonym More Synonyms

 FR-167356 Biological Activity

Description FR-167356 is a potent, orally active and selective vacuolar ATPase inhibitor with IC50 values of 170, 220, 370, and 1200 nM for osteoclast plasma membranes, macrophage microsomes, renal brush border membranes, and liver lysosomal membranes, respectively. FR-167356 inhibits bone resorption and ovariectomy-induced bone loss[1].
Related Catalog
In Vivo FR-167356 (200 mg/kg; 口服; 每天, 持续 10 天; 具有 B16-F10 异种移植物的雄性 C57BL/6 小鼠) 抑制肿瘤生长并降低 MMP9 表达[1]。 FR-167356 (200 mg/kg; 口服; 每天, 持续 10 天; 具有 B16-F10 异种移植物的雄性 C57BL/6 小鼠) 与未治疗组相比减少骨转移[1]。 Animal Model: male C57BL/6 mice with B16-F10 xenografts[1] Dosage: 200 mg/kg Administration: Oral administration; daily, for 10 days Result: Reduced the expression of MMP9 and reduced bone metastasis.
References

[1]. Nishisho T, et, al. The a3 isoform vacuolar type H⁺-ATPase promotes distant metastasis in the mouse B16 melanoma cells. Mol Cancer Res. 2011 Jul;9(7):845-55.  

[2]. Niikura K, et, al. A vacuolar ATPase inhibitor, FR167356, prevents bone resorption in ovariectomized rats with high potency and specificity: potential for clinical application. J Bone Miner Res. 2005 Sep;20(9):1579-88.  

 Chemical & Physical Properties

Density 1.385 g/cm3
Boiling Point 422.714ºC at 760 mmHg
Molecular Formula C19H17Cl2NO3
Molecular Weight 378.24900
Flash Point 209.45ºC
Exact Mass 377.05900
PSA 65.96000
LogP 5.91170

 Synonyms

unii-xf02b1hc8r