Allopregnanolone-d4

Modify Date: 2024-01-03 09:48:59

Allopregnanolone-d4 structure	Common Name	Allopregnanolone-d4
	CAS Number	203805-85-0	Molecular Weight	322.518
	Density	1.1±0.1 g/cm3	Boiling Point	431.2±18.0 °C at 760 mmHg
	Molecular Formula	C₂₁H₃₀D₄O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	183.9±13.8 °C

Use of Allopregnanolone-d4

Allopregnanolone-d4 is the deuterium labeled Allopregnanolone. Allopregnanolone (Brexanolone), a metabolite of progesterone, is a positive allosteric modulator of GABAA receptors. Allopregnanolone modulates dopamine levels in the nucleus accumbens and prefrontal cortex. Allopregnanolone stimulates food intake and weight gain[1].

Name	(3α,5α,8α)-3-Hydroxy(1,2,2,3-2H4)pregnan-20-one
Synonym	More Synonyms

Description	Allopregnanolone-d4 is the deuterium labeled Allopregnanolone. Allopregnanolone (Brexanolone), a metabolite of progesterone, is a positive allosteric modulator of GABAA receptors. Allopregnanolone modulates dopamine levels in the nucleus accumbens and prefrontal cortex. Allopregnanolone stimulates food intake and weight gain[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Dornellas APS, et al. Allopregnanolone Decreases Evoked Dopamine Release Differently in Rats by Sex and Estrous Stage. Front Pharmacol. 2021;11:608887. Published 2021 Jan 14. [3]. Kimball A, et al. The allopregnanolone to progesterone ratio across the menstrual cycle and in menopause. Psychoneuroendocrinology. 2020;112:104512.

Density	1.1±0.1 g/cm3
Boiling Point	431.2±18.0 °C at 760 mmHg
Molecular Formula	C₂₁H₃₀D₄O₂
Molecular Weight	322.518
Flash Point	183.9±13.8 °C
Exact Mass	322.280975
LogP	4.89
Vapour Pressure	0.0±2.3 mmHg at 25°C
Index of Refraction	1.524

(3α,5α,8α)-3-Hydroxy(1,2,2,3-H)pregnan-20-one

Pregnan-20-one-1,2,2,3-d, 3-hydroxy-, (3α,5α,8α)-

Allopregnanolone-d4

Use of Allopregnanolone-d4

Names

Allopregnanolone-d4 Biological Activity

Chemical & Physical Properties

Synonyms