EGFR-IN-57

Modify Date: 2024-01-08 17:15:24

EGFR-IN-57 structure	Common Name	EGFR-IN-57
	CAS Number	2492382-37-1	Molecular Weight	385.44
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₁₅N₃O₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of EGFR-IN-57

EGFR-IN-57 (Compound 25a) is a potent, orally active EGFR-TK inhibitor with an IC50 of 0.054 µM. EGFR-IN-57 also inhibits VEGFR-2, CK2α, topoisomerase IIβ and tubulin polymerization with IC50 values of 0.087, 0.171, 0.13 and 3.61 µM, respectively. EGFR-IN-57 induces cell cycle arrest at G2/M and pre-G1 phases. EGFR-IN-57 induces cancer cell apoptosis[1].

Name	EGFR-IN-57

Description	EGFR-IN-57 (Compound 25a) is a potent, orally active EGFR-TK inhibitor with an IC50 of 0.054 µM. EGFR-IN-57 also inhibits VEGFR-2, CK2α, topoisomerase IIβ and tubulin polymerization with IC50 values of 0.087, 0.171, 0.13 and 3.61 µM, respectively. EGFR-IN-57 induces cell cycle arrest at G2/M and pre-G1 phases. EGFR-IN-57 induces cancer cell apoptosis[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR Signaling Pathways >> Cell Cycle/DNA Damage >> Casein Kinase Signaling Pathways >> Stem Cell/Wnt >> Casein Kinase
Target	EGFR:0.054 μM (IC50) VEGFR-2:0.087 μM (IC50) CK2α:0.171 μM (IC50) topoisomerase II beta:0.13 μM (IC50) tubulin polymerization:3.16 μM (IC50)
References	[1]. Warda ET, et al. New series of isoxazole derivatives targeting EGFR-TK: Synthesis, molecular modeling and antitumor evaluation. Bioorg Med Chem. 2020 Nov 1;28(21):115674.

Molecular Formula	C₂₂H₁₅N₃O₂S
Molecular Weight	385.44

EGFR-IN-57

Use of EGFR-IN-57

Names

EGFR-IN-57 Biological Activity

Chemical & Physical Properties