9-[(4aR,6R,7R,7aS)-2,7-dihydroxy-2-sulfanylidene-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-2-amino-8-(4-chlorophenyl)sulfanyl-3H-purin-6-one,N,N-diethylethanamine
![9-[(4aR,6R,7R,7aS)-2,7-dihydroxy-2-sulfanylidene-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-2-amino-8-(4-chlorophenyl)sulfanyl-3H-purin-6-one,N,N-diethylethanamine Structure](https://image.chemsrc.com/caspic/085/276696-61-8.png)
9-[(4aR,6R,7R,7aS)-2,7-dihydroxy-2-sulfanylidene-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-2-amino-8-(4-chlorophenyl)sulfanyl-3H-purin-6-one,N,N-diethylethanamine structure
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Common Name | 9-[(4aR,6R,7R,7aS)-2,7-dihydroxy-2-sulfanylidene-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-2-amino-8-(4-chlorophenyl)sulfanyl-3H-purin-6-one,N,N-diethylethanamine | ||
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| CAS Number | 276696-61-8 | Molecular Weight | 605.06700 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H30ClN6O6PS2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
| Name | 9-[(4aR,6R,7R,7aS)-2,7-dihydroxy-2-sulfanylidene-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-2-amino-8-(4-chlorophenyl)sulfanyl-3H-purin-6-one,N,N-diethylethanamine |
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| Synonym | More Synonyms |
| Molecular Formula | C22H30ClN6O6PS2 |
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| Molecular Weight | 605.06700 |
| Exact Mass | 604.10900 |
| PSA | 229.17000 |
| LogP | 3.73800 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
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(Rp)-8-pCPT-cGMPS, a novel cGMP-dependent protein kinase inhibitor.
Eur. J. Pharmacol. 269 , 265-268, (1994) In the present study, the inhibitory effect of the cGMP analog (Rp)-8-(para-chlorophenylthio)guanosine-3',5'-cyclic monophosphorothioate ((Rp)-8-pCPT-cGMPS) on the cGMP-dependent protein kinase-mediat... |
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Nitric oxide and carbon monoxide activate locus coeruleus neurons through a cGMP-dependent protein kinase: involvement of a nonselective cationic channel.
J. Neurosci. 16 , 1389-1399, (1996) Nitric oxide (NO) and carbon monoxide (CO) have been identified as two diffusible signaling messengers in the brain, capable of stimulating soluble guanylate cyclase. Locus coeruleus (LC) is rich in t... |
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The nitric oxide/cGMP pathway couples muscarinic receptors to the activation of Ca2+ influx.
J. Neurosci. 16 , 1702-1709, (1996) Inward currents activated by 8-bromc-cGMP and by muscarinic agonist were compared in N1E-115 mouse neuroblastoma cells using perforated-patch voltage clamp and Fura-2 imaging. The cGMP analog activate... |
| 8-(4-Chlorophenylthio)-guanosine 3 inverted exclamation marka,5 inverted exclamation marka-cyclic monophosphorothioate,Rp Isomer triethylammonium salt |
| Rp-8-CPT-cGMPS |
| Rp-8-[(4-Chlorophenyl)thio]-guanosine-cyclic 3 inverted exclamation marka,5 inverted exclamation marka-hydrogen phosphorothioate triethylammonium salt |
| Rp-8-[(4-Chlorophenyl)thio]-cGMPS triethylammonium salt |