GS-389

Modify Date: 2024-01-12 18:09:04

GS-389 Structure
GS-389 structure
Common Name GS-389
CAS Number 41498-37-7 Molecular Weight 313.39100
Density 1.108g/cm3 Boiling Point 454ºC at 760 mmHg
Molecular Formula C19H23NO3 Melting Point N/A
MSDS N/A Flash Point 191.6ºC

 Use of GS-389


GS 389 ((±)-O,O-Dimethylcoclaurine) is a tetrahydroisoquinoline. GS-389 inhibites Cyclic AMP and cyclic AMP dependent phosphodiesterases from rat atrial and ventricular tissue. GS-389 relaxes the contraction induced by phenylephrine and high K+ in rat aortic rings[1].

 Names

Name 6,7-dimethoxy-1-[(4-methoxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline
Synonym More Synonyms

 GS-389 Biological Activity

Description GS 389 ((±)-O,O-Dimethylcoclaurine) is a tetrahydroisoquinoline. GS-389 inhibites Cyclic AMP and cyclic AMP dependent phosphodiesterases from rat atrial and ventricular tissue. GS-389 relaxes the contraction induced by phenylephrine and high K+ in rat aortic rings[1].
Related Catalog
References

[1]. Chang KC, et al. Different pharmacological characteristics of structurally similar benzylisoquinoline analogs, papaverine, higenamine, and GS 389, on isolated rat aorta and heart. Can J Physiol Pharmacol. 1994;72(4):327-334.  

 Chemical & Physical Properties

Density 1.108g/cm3
Boiling Point 454ºC at 760 mmHg
Molecular Formula C19H23NO3
Molecular Weight 313.39100
Flash Point 191.6ºC
Exact Mass 313.16800
PSA 39.72000
LogP 3.47070
Index of Refraction 1.557

 Safety Information

HS Code 2933499090

 Synthetic Route

 Customs

HS Code 2933499090
Summary 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

coclaurine dimethyl ether
1,2,3,4-tetrahydro-6,7-dimethoxy-1-[(4-methoxyphenyl)methyl]isoquinoline
7,12-O,O'-dimethylcoclaurine
N-(3,4-dimethoxyphenylethyl)-2-(3-methoxyphenyl)acetamide
6,7-dimethoxy-1-(4-methoxy-benzyl)-1,2,3,4-tetrahydroisoquinoline
rac-O,O-dimethylcoclaurine
GS-389
(+/-)-1-(4-methoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline