GC 14

Modify Date: 2024-01-04 12:00:17

GC 14 structure	Common Name	GC 14
	CAS Number	447415-34-1	Molecular Weight	449.5
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₆H₂₇NO₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of GC 14

GC 14 is a thyroid hormone antagonist.

Name	GC 14

Description	GC 14 is a thyroid hormone antagonist.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
Target	Thyroid hormone[1][2]
In Vitro	GC 14 contains extensions at the 5′-position of the outer thyronine ring or from the bridging carbon and has only a modest affinity and potency for the thyroid hormone receptor (TR) that limits studies of their antagonistic actions[2].
References	[1]. Chiellini G, et al. Synthesis and biological activity of novel thyroid hormone analogues: 5'-aryl substituted GC-1 derivatives. Bioorg Med Chem. 2002 Feb;10(2):333-46. [2]. Nguyen NH, et al. Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment. J Med Chem. 2002 Jul 18;45(15):3310-20.

Molecular Formula	C₂₆H₂₇NO₆
Molecular Weight	449.5