19721-56-3

• 常用中文名：吡罗霉素
• 常用英文名：Picromycin
• CAS号：19721-56-3
• 分子式：C₂₈H₄₇NO₈
• 分子量：525.67
• 相关类别： 信号通路 抗感染 细菌
• 发布时间：2017-12-11 05:11:25
• 更新时间：2024-01-02 20:08:57
• 吡咯霉素是一种大环内酯类抗生素,已在委内瑞拉链球菌中发现,对大肠杆菌、金黄色葡萄球菌和枯草杆菌具有活性[1]。

名称

• 中文名: 吡罗霉素
• 英文名: pikromycin
• 英文别名: Albomycetin; picromycin; Pikromycin; Amaromycin

物化性质

• 密度: 1.14g/cm3
• 沸点: 688.1ºC at 760mmHg
• 分子式: C₂₈H₄₇NO₈
• 分子量: 525.67
• 闪点: 369.9ºC
• 精确质量: 525.33000
• PSA: 122.60000
• LogP: 2.51290
• 蒸汽压: 6.51E-22mmHg at 25°C
• 折射率: 1.521

生物活性

• 描述: 吡咯霉素是一种大环内酯类抗生素,已在委内瑞拉链球菌中发现,对大肠杆菌、金黄色葡萄球菌和枯草杆菌具有活性[1]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. Gupta S, et al. Generation of novel pikromycin antibiotic products through mutasynthesis. Chembiochem. 2008 Jul 2;9(10):1609-16.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TJ8225000 CHEMICAL NAME : Picromycin CAS REGISTRY NUMBER : 19721-56-3 LAST UPDATED : 199510 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C28-H47-N-O8 MOLECULAR WEIGHT : 525.76 WISWESSER LINE NOTATION : T-12-OV HV IUTJ C1 E1 G1 KQ K1 L2 FO- BT6OTJ CQ DN1&1 F1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 50 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 93,287,1948 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,114,1967 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 249 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,114,1967 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,114,1967 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 125 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,144,1967 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intracerebral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 508 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 1,101,1978