84226-06-2

• 常用中文名：IBZM
• 常用英文名：IBZM
• CAS号：84226-06-2
• 分子式：C₁₅H₂₁IN₂O₃
• 分子量：404.24300
• 发布时间：2017-06-11 19:19:43
• 更新时间：2024-01-11 12:38:00

名称

• 英文名: benzamide, n-[(1-ethyl-2-pyrrolidinyl)methyl]-2-hydroxy-3-iodo-6-methoxy
• 英文别名: IBZM; (s)-benzamid; N-[[(2S)-1-Ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-3-iodo-6-methoxybenzamide; S-(-)-IBZM; IODOBENZAMIDE,(S)-(-)-3-IODO-2-HYDROXY-6-METHOXY-N[(1-ETHYL-2-PYRROLIDINYL)METHYL]BENZAMIDE; 3-iodo-2-hydroxy-6-methoxy-n-((1-ethyl-2-pyrrolidinyl)methyl)benzamide; [123I]-IBZM; (s)-n-(1-ethyl-2-pyrrolidinyl)methyl-2-hydroxy-3-iodo-6-methoxybenzamide; (S)-N-(1-ethylpyrrolidin-2-ylmethyl)-2-hydroxy-3-iodo-6-methoxybenzamide; (S)-(-)-3-iodo-2-hydroxy-6-methoxy-N-[(1-ethyl-2-pyrrolidinyl)methyl]benzamide

物化性质

• 密度: 1.51 g/cm3
• 沸点: 426.9ºC at 760 mmHg
• 分子式: C₁₅H₂₁IN₂O₃
• 分子量: 404.24300
• 闪点: 212ºC
• 精确质量: 404.06000
• PSA: 61.80000
• LogP: 2.54830
• 外观性状: 暗黄色油状

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : CV4927050 CHEMICAL NAME : Benzamide, N-((1-ethyl-2-pyrrolidinyl)methyl)-2-hydroxy-3-iodo-6 -methoxy-, (S)- CAS REGISTRY NUMBER : 84226-06-2 LAST UPDATED : 199612 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C15-H21-I-N2-O3 MOLECULAR WEIGHT : 404.28 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 400 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 11,433,1988 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 50 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - chronic pulmonary edema REFERENCE : DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 11,433,1988

合成路线

96897-88-0 ~72% 84226-06-2 132448-74-9

文献：de Paulis; Kumar; Johansson; Raemsby; Florvall; Hall; Angeby-Moeller; Ogren Journal of Medicinal Chemistry, 1985 , vol. 28, # 9 p. 1263 - 1269

3147-64-6 ~% 84226-06-2

文献：Journal of Medicinal Chemistry, , vol. 31, # 5 p. 1039 - 1043

1466-76-8 ~% 84226-06-2

文献：Journal of Medicinal Chemistry, , vol. 31, # 5 p. 1039 - 1043

113452-76-9 ~% 84226-06-2

文献：Journal of Medicinal Chemistry, , vol. 31, # 5 p. 1039 - 1043

90347-70-9 ~% 84226-06-2

文献：Journal of Medicinal Chemistry, , vol. 28, # 9 p. 1263 - 1269

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3147-64-6 1466-76-8 113452-76-9 90347-70-9
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