3810-80-8

• 常用中文名：地芬诺酯盐酸盐
• 常用英文名：diphenoxylate hydrochloride
• CAS号：3810-80-8
• 分子式：C₃₀H₃₃ClN₂O₂
• 分子量：489.048
• 相关类别： 分析化学 标准品 药典标准品和杂志标准品
• 发布时间：2018-02-09 08:00:00
• 更新时间：2024-01-08 19:24:56
• 用于急、慢性功能性腹泻及慢性肠炎等 包 装: 25KG/DRUM

名称

• 中文名: 地芬诺酯盐酸盐
• 英文名: diphenoxylate hydrochloride
• 中文别名: 盐酸地芬诺酯(苯乙哌啶粉)
• 英文别名: Ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylate hydrochloride (1:1); DIPHENOXYLATE HYDROCHLORIDE; ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylate hydrochloride; 4-Piperidinecarboxylic acid, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-, ethyl ester, hydrochloride (1:1); DIPHENOXYLATE HYDROCHLORIDE ANTIPERISTAL TIC,ANTI; Ethyl-1-(3-cyan-3,3-diphenylpropyl)-4-phenylpiperidin-4-carboxylathydrochlorid; DIPHENOXYLATE HCL; Ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-4-piperidinecarboxylate hydrochloride (1:1); 1-(3-Cyano-3,3-diphenylpropyl)-4-phenyl-4-piperidinecarboxylic Acid Ethyl Ester Monohydrochloride; 1-(3-cyano-3,3-diphénylpropyl)-4-phénylpipéridine-4-carboxylate d'éthyle chlorhydrate; r1132; 4-Ethoxycarbonyl-α,α,4-triphenyl-1-piperidinebutyronitrile, hydrochloride

物化性质

• 沸点: 602.3ºC at 760mmHg
• 熔点: 220.0-222.5ºC
• 分子式: C₃₀H₃₃ClN₂O₂
• 分子量: 489.048
• 闪点: 318ºC
• 精确质量: 488.223053
• PSA: 53.33000
• LogP: 6.22318
• 储存条件: 库房低温,通风,干燥,与食品原料分开存放
• 水溶解性: Very slightly soluble in water, freely soluble in methylene chloride, sparingly soluble in ethanol (96 per cent).

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NS5300000 CHEMICAL NAME : Isonipecotic acid, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-, ethyl ester, hydrochloride CAS REGISTRY NUMBER : 3810-80-8 LAST UPDATED : 199712 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C30-H32-N2-O2.Cl-H MOLECULAR WEIGHT : 489.10 WISWESSER LINE NOTATION : T6NTJ A2XR&R&CN DVO2 DR &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 221 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 24,1633,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >320 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 24,1636,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >160 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 24,1636,1974 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3182 No. of Facilities: 105 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 8242 (estimated) No. of Female Employees: 7235 (estimated)

安全

• 危险品运输编码: UN 1544
• 包装等级: III
• 危险类别: 6.1(b)