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2'-Deoxy-6-O-[2-(4-nitrophenyl)ethyl]guanosine

更新时间:2024-01-14 11:41:46

2'-Deoxy-6-O-[2-(4-nitrophenyl)ethyl]guanosine结构式
2'-Deoxy-6-O-[2-(4-nitrophenyl)ethyl]guanosine结构式
品牌特惠专场
常用名 2'-Deoxy-6-O-[2-(4-nitrophenyl)ethyl]guanosine 英文名 2'-Deoxy-6-O-[2-(4-nitrophenyl)ethyl]guanosine
CAS号 86137-72-6 分子量 416.39
密度 N/A 沸点 N/A
分子式 C18H20N6O6 熔点 N/A
MSDS N/A 闪点 N/A

 用途


2'-脱氧-O6-[2-(4-硝基苯乙基)]鸟苷是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。

 名称

英文名 2'-deoxy-O6-[2-(4-nitrophenyl)ethyl]guanosine
英文别名 更多

 生物活性

描述 2'-脱氧-O6-[2-(4-硝基苯乙基)]鸟苷是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。
相关类别
参考文献

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

 物理化学性质

分子式 C18H20N6O6
分子量 416.39
精确质量 416.14400
PSA 174.36000
LogP 1.68330

 合成线路

~%

2'-Deoxy-6-O-[2-(4-nitrophenyl)ethyl]guanosine结构式

2'-Deoxy-6-O-[2...

86137-72-6

文献:He; Krawczyk; Swaminathan; Shea; Dougherty; Terhorst; Law; Griffin; Coutre; Bischofberger Journal of medicinal chemistry, 1998 ,  vol. 41,  # 13  p. 2234 - 2242

 英文别名

2'-DEOXY-6-O-[2-(4-NITROPHENYL)ETHYL]GUANOSINE
6-O-(4-nitrophenylethyl)-2''-deoxyguanosine
O-6-(p-nitrophenylethyl)-2''-deoxyguanosine
2''-deoxy-O6-[2-(4-nitrophenyl)ethyl]guanosine
6-O-(tert-Butyldiphenylsilyl)-3,4-O-isopropylidene-D-galactal
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