二乙氨基乙醇

二乙氨基乙醇用途

【用途一】
用作医药中间体、软化剂、乳化剂、固化剂等
【用途二】
用于有机合成及制药工业，也用作酸性媒质乳化剂
【用途三】
该品是医药中间体。用于制取普鲁卡因盐酸盐、咳必清、咳美芬、胃复康、延通心等。也用作溶剂，脱除天然气，炼厂气中的酸性气体，如硫化氢及二氧化碳。也可以制取脂肪酸的衍生物，纤维柔软剂，防锈剂，乳化剂，聚氨酯泡沫塑料的硫化催化剂及组分等。
【用途四】
主要用于医药中间体，有机合成及天然气中酸性气体的脱除。

二乙氨基乙醇名称

[ CAS 号 ]:
100-37-8

[ 中文名 ]:
二乙氨基乙醇

[ 英文名 ]:
2-(Diethylamino)ethanol

[中文别名 ]:

[英文别名 ]:

N,N-Diethylethanolamine
Diethylaminoethanol
2-(Diethylamino)ethanol
2-Diethylaminoethanol
EINECS 202-845-2
MFCD00002850
2-Hydroxytriethylamine
Ethanol, 2-(diethylamino)-

二乙氨基乙醇物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
164.8±13.0 °C at 760 mmHg

[ 熔点 ]:
-70 °C

[ 分子式 ]:
C₆H₁₅NO

[ 分子量 ]:
117.189

[ 闪点 ]:
48.9±0.0 °C

[ 精确质量 ]:
117.115364

[ PSA ]:
23.47000

[ LogP ]:
0.74

[ 外观性状 ]:
透明至淡黄色液体

[ 蒸汽密度 ]:
4.04 (vs air)

[ 蒸汽压 ]:
0.7±0.7 mmHg at 25°C

[ 折射率 ]:
1.443

[ 储存条件 ]:
库房通风低温干燥,与氧化剂,酸类分开储运

[ 稳定性 ]:
Stable. Flammable. Incompatible with strong oxidizing agents, acids. Moisture sensitive. Hygroscopic.

[ 水溶解性 ]:
soluble

[ 凝固点 ]:
-70℃

二乙氨基乙醇MSDS

详细MSDS(安全技术说明书)

二乙氨基乙醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KK5075000

CHEMICAL NAME :: Ethanol, 2-(diethylamino)-

CAS REGISTRY NUMBER :: 100-37-8

LAST UPDATED :: 199712

DATA ITEMS CITED :: 46

MOLECULAR FORMULA :: C6-H15-N-O

MOLECULAR WEIGHT :: 117.22

WISWESSER LINE NOTATION :: Q2N2&2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 26,269,1944

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 6/11/1963

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 6/11/1963 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Human

DOSE/DURATION :: 200 ppm

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting

REFERENCE :: 34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 Volume(issue)/page/year: -,216,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 26,269,1944

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4500 mg/m3/4H

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Sense Organs and Special Senses (Eye) - conjunctive irritation Behavioral - convulsions or effect on seizure threshold

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 14(11),52,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1220 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 12,486,1968

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5000 mg/m3

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Sense Organs and Special Senses (Eye) - conjunctive irritation Behavioral - convulsions or effect on seizure threshold

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 14(11),52,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 192 mg/kg

TOXIC EFFECTS :: Behavioral - ataxia

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 94,249,1948

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 650 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - other changes

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,31,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 188 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,31,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 416 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,31,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1260 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 6/11/1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1 mL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 26,269,1944

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 1300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 Volume(issue)/page/year: -,216,1969 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 ppm/6H/5D-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Related to Chronic Data - death

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 26,479,1965

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 ppm/6H/26W-I

TOXIC EFFECTS :: Related to Chronic Data - death

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 26,479,1965

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 76 ppm/6H/14W-I

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 18,418,1992

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 301 ppm/6H/2W-I

TOXIC EFFECTS :: Behavioral - fluid intake Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 18,418,1992

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 21559 mg/kg/1Y-C

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0530455-1 *** REVIEWS *** ACGIH TLV-TWA 9.6 mg/m3 (2 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 10 ppm (50 mg/m3) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,85,1971 OSHA PEL (Gen Indu):8H TWA 10 ppm (50 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 10 ppm (50 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 10 ppm (50 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 10 ppm (50 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 10 ppm (50 mg/m3);Skin JAN 1993 OEL-AUSTRIA:TWA 10 ppm (50 mg/m3);Skin JAN 1993 OEL-BELGIUM:TWA 10 ppm (48 mg/m3);Skin JAN 1993 OEL-DENMARK:TWA 10 ppm (50 mg/m3);Skin JAN 1993 OEL-FINLAND:STEL 10 ppm (50 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 10 ppm (50 mg/m3);Skin JAN 1993 OEL-GERMANY:TWA 10 ppm (50 mg/m3);Skin JAN 1993 OEL-THE NETHERLANDS:TWA 10 ppm (50 mg/m3);Skin JAN 1993 OEL-THE PHILIPPINES:TWA 10 ppm (50 mg/m3);Skin JAN 1993 OEL-RUSSIA:STEL 5 mg/m3;Skin JAN 1993 OEL-SWITZERLAND:TWA 10 ppm (50 mg/m3);Skin JAN 1993 OEL-UNITED KINGDOM:TWA 10 ppm (50 mg/m3);Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO 2-DIETHYLAMINOETHANOL-air:10H TWA 10 ppm (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 24930 No. of Facilities: 7801 (estimated) No. of Industries: 71 No. of Occupations: 39 No. of Employees: 23770 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 24930 No. of Facilities: 11825 (estimated) No. of Industries: 115 No. of Occupations: 68 No. of Employees: 106878 (estimated) No. of Female Employees: 20564 (estimated)

二乙氨基乙醇安全信息

[ 符号 ]:

GHS02, GHS05, GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H226-H302-H311 + H331-H314

[ 警示性声明 ]:
P210-P280-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338-P370 + P378

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
C:Corrosive

[ 风险声明 (欧洲) ]:
R10;R20/21/22;R34

[ 安全声明 (欧洲) ]:
S25-S26-S36/37/39-S45

[ 危险品运输编码 ]:
UN 2686 8/PG 2

[ WGK德国 ]:
1

[ RTECS号 ]:
KK5075000

[ 包装等级 ]:
II

[ 危险类别 ]:
8

[ 海关编码 ]:
2922192210

二乙氨基乙醇合成路线

详细合成路线

二乙氨基乙醇上下游产品

二乙氨基乙醇上游产品

二乙氨基乙醇下游产品

二乙氨基乙醇制备

1.将氯乙醇与氢氧化钠在105℃下进行反应，生成环氧乙烷，通入二乙胺溶液中进行反应，在常压下分出低沸物后，减压分馏得N，N-二乙基乙醇胺成品。目前大部分生产厂直接用环氧乙烷作原料。

精制方法：常压或减压蒸馏精制。

2.以二乙胺和环氧乙烷原料，将环氧乙烷加入二乙胺中，在一定温度下反应，所得粗品经减压蒸馏成纯品。反应式如下：

二乙氨基乙醇海关

[ 海关编码 ]: 2922192210

[ 中文概述 ]:
2922192210 2－二乙氨基乙醇〔或称N,N－二乙基乙醇胺〕。监管条件:3(两用物项和技术出口许可证)。增值税率:17.0%。退税率:9.0%。最低关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: 3.两用物项和技术出口许可证

[ Summary ]:
2922192210 2-(diethylamino)ethanol。supervision conditions:3(export license for dual-use item and technologies)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:30.0%

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