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环己酮肟

环己酮肟用途

【用途一】
用于有机合成

环己酮肟名称

[ CAS 号 ]:
100-64-1

[ 中文名 ]:
环己酮肟

[ 英文名 ]:
Cyclohexanone oxime

[英文别名 ]:

N-cyclohexylidenehydroxylamine
Cyclohexanone oxime
EINECS 202-874-0
Cyclohexanone, oxime
N-Hydroxycyclohexanimine
Cyclohexylimine
MFCD00001660

环己酮肟物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
208.0±0.0 °C at 760 mmHg

[ 熔点 ]:
86-89 °C(lit.)

[ 分子式 ]:
C₆H₁₁NO

[ 分子量 ]:
113.158

[ 闪点 ]:
112.4±8.0 °C

[ 精确质量 ]:
113.084061

[ PSA ]:
32.59000

[ LogP ]:
1.12

[ 外观性状 ]:
灰色晶体

[ 蒸汽压 ]:
0.1±0.8 mmHg at 25°C

[ 折射率 ]:
1.529

[ 储存条件 ]:
室温

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents. Reacts violently with fuming sulfuric acid at elevated temperature.

[ 水溶解性 ]:
<0.1 g/100 mL at 20 ºC

环己酮肟MSDS

环己酮肟毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GW1925000

CHEMICAL NAME :: Cyclohexanone, oxime

CAS REGISTRY NUMBER :: 100-64-1

BEILSTEIN REFERENCE NO. :: 1616769

LAST UPDATED :: 199712

DATA ITEMS CITED :: 15

MOLECULAR FORMULA :: C6-H11-N-O

MOLECULAR WEIGHT :: 113.18

WISWESSER LINE NOTATION :: L6YTJ AUNQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 710 mg/kg

TOXIC EFFECTS :: Autonomic Nervous System - smooth muscle relaxant (mechanism undefined, spasmolytic)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 mg/kg/2W-I

TOXIC EFFECTS :: Endocrine - changes in spleen weight Blood - changes in erythrocyte (RBC) count Blood - changes in leukocyte (WBC) count

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1625 mg/kg/13W-I

TOXIC EFFECTS :: Endocrine - changes in spleen weight Blood - changes in erythrocyte (RBC) count Blood - changes in leukocyte (WBC) count

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 mg/m3/24H/90D-C

TOXIC EFFECTS :: Blood - methemoglobinemia-carboxyhemoglobin Blood - changes in erythrocyte (RBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 175 mg/kg/2W-C

TOXIC EFFECTS :: Liver - changes in liver weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 26117 mg/kg/13W-C

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - deviated nasal septum Liver - other changes Kidney, Ureter, Bladder - changes in bladder weight

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - mouse Lymphocyte

DOSE/DURATION :: 1938 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 204,149,1988 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 10 mg/m3 JAN 1993

环己酮肟安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S36/37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
GW1925000

[ 海关编码 ]:
29280090

环己酮肟合成路线

环己酮肟上下游产品

环己酮肟上游产品

环己酮肟下游产品

环己酮肟制备

环己酮肟是己内酰胺生产过程中的中间产物。

环己酮肟海关

[ 海关编码 ]: 29280090

环己酮肟文献

Oxidative effects in human erythrocytes caused by some oximes and hydroxylamine.

Arch. Toxicol. 72(5) , 270-6, (1998)

Both oximes and hydroxylamine (HYAM) are compounds with known oxidative capacity. We tested in vitro whether acetaldoxime (AAO), cyclohexanone oxime (CHO), methyl ethyl ketoxime (MEKO) or HYAM affect ...

Hierarchically structured monolithic silicalite-1 consisting of crystallized nanoparticles and its performance in the Beckmann rearrangement of cyclohexanone oxime.

J. Am. Chem. Soc. 127(36) , 12595-600, (2005)

In this study, we present a synthetic pathway for the fabrication of self-supporting zeolite monoliths consisting of crystallized nanoparticles. A resorcinol-formaldehyde-based organic aerogel is used...

Oximes: metabolic activation and structure-allergenic activity relationships.

J. Med. Chem. 51 , 2541-50, (2008)

Metabolic activation of chemicals (prohaptens) in the skin can cause allergic contact dermatitis. We have explored structure-allergenic activity relationships for seven potential oxime prohaptens usin...

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