苯甲醚

苯甲醚用途

用途一：苯甲醚用于生产香料、染料、医药、农药，也用作溶剂
用途二：用作分析试剂、溶剂，也用于香料及肠内杀虫剂制备
用途三：GB 2760—1996规定为允许使用的食品用香料。主要用于配制香草、茴香和啤酒型香精。
用途四：用于有机合成，也用作溶剂、香料和驱虫剂。
用途五：用作重结晶的溶剂，恒温器填充剂，测折光率，香料、有机合成中间体

苯甲醚名称

[ CAS 号 ]:
100-66-3

[ 中文名 ]:
苯甲醚

[ 英文名 ]:
Anisole

[中文别名 ]:

茴香醚

[英文别名 ]:

Methoxybenzene
Ether, methyl phenyl
Phenol methyl ether
Phenyl methyl ether
Phenoxymethane
Anizol
EINECS 202-876-1
Anisole
Benzene, methoxy
4-methoxybenzene

苯甲醚物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
153.6±0.0 °C at 760 mmHg

[ 熔点 ]:
-37 °C

[ 分子式 ]:
C₇H₈O

[ 分子量 ]:
108.138

[ 闪点 ]:
51.7±0.0 °C

[ 精确质量 ]:
108.057518

[ PSA ]:
9.23000

[ LogP ]:
2.13

[ 外观性状 ]:
透明稻黄色的液体

[ 蒸汽密度 ]:
3.7 (vs air)

[ 蒸汽压 ]:
4.2±0.2 mmHg at 25°C

[ 折射率 ]:
1.492

[ 储存条件 ]:
包装完整、轻装轻放,库房通风、远离明火、高温、与氧化剂分开存放

[ 稳定性 ]:
Stable. Flammable. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
1.6 g/L (20 ºC)

苯甲醚MSDS

详细MSDS(安全技术说明书)

苯甲醚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BZ8050000

CHEMICAL NAME :: Anisole

CAS REGISTRY NUMBER :: 100-66-3

LAST UPDATED :: 199710

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C7-H8-O

MOLECULAR WEIGHT :: 108.15

WISWESSER LINE NOTATION :: 1OR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3700 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - changes in structure or function of salivary glands Kidney, Ureter, Bladder - hematuria

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5000 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2800 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3021 mg/m3/2H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 25 umol/L

REFERENCE :: RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 54,133,1986 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 10 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1533 No. of Facilities: 4 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 469 (estimated)

苯甲醚安全信息

[ 符号 ]:

GHS02

[ 信号词 ]:
Warning

[ 危害声明 ]:
H226

[ 补充危害声明 ]:
Repeated exposure may cause skin dryness or cracking.

[ 警示性声明 ]:
P210-P370 + P378

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R10;R20;R38

[ 安全声明 (欧洲) ]:
S37/39-S26-S16-S24/25

[ 危险品运输编码 ]:
UN 2222 3/PG 3

[ WGK德国 ]:
2

[ RTECS号 ]:
BZ8050000

[ 包装等级 ]:
III

[ 危险类别 ]:
3

苯甲醚上下游产品

苯甲醚上游产品

苯甲醚下游产品

苯甲醚制备

由甲基化剂硫酸二甲酯在碱性溶液中与苯酚反应制得。将苯酚与氢氧化钠溶液混合，于10℃以下缓缓加入硫酸二甲酯。加毕，升温至40℃回流反应18h，然后静置分出油层，用无水氯化钙干燥后减夺蒸馏而得苯甲醚。

将甲基氯通入苯酚钠的液氨中反应而得。
由苯酚和甲醇共热而得。
由苯酚和硫酸二甲酯在氢氧化钠存在下反应而得。

苯甲醚文献

Polyethylene Glycol Coatings on Plastic Substrates for Chemically Defined Stem Cell Culture.

Adv. Healthc. Mater. 4 , 1555-64, (2015)

Human mesenchymal stem cells (hMSCs) are a widely available and clinically relevant cell type with a host of applications in regenerative medicine. Current clinical expansion methods can lead to selec...

The ionization mechanisms in direct and dopant-assisted atmospheric pressure photoionization and atmospheric pressure laser ionization.

J. Am. Soc. Mass Spectrom. 25(11) , 1870-81, (2014)

A novel, gas-tight API interface for gas chromatography-mass spectrometry was used to study the ionization mechanism in direct and dopant-assisted atmospheric pressure photoionization (APPI) and atmos...

Convenient QSAR model for predicting the complexation of structurally diverse compounds with β-cyclodextrins

Bioorg. Med. Chem. 17 , 896-904, (2009)

This paper reports a QSAR study for predicting the complexation of a large and heterogeneous variety of substances (233 organic compounds) with beta-cyclodextrins (beta-CDs). Several different theoret...

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苯甲醚