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4-甲基苯甲醚(MSO)

4-甲基苯甲醚(MSO)用途

4-Methylanisole (4-Methoxytoluene) 是食品调味剂,存在于依兰香油中。

4-甲基苯甲醚(MSO)名称

[ CAS 号 ]:
104-93-8

[ 中文名 ]:
对甲苯甲醚

[ 英文名 ]:
4-Methylanisole

[中文别名 ]:

[英文别名 ]:

1-Methoxy-4-methylbenzene
p-Methoxytoluene
MFCD00008413
4-Methylanisole
Benzene, 1-methoxy-4-methyl-
p-Cresol Methyl Ether
4-Methoxytoluene
EINECS 203-253-7
Methyl 4-methylphenyl ether

4-甲基苯甲醚(MSO)生物活性

[ 描述 ]:

4-Methylanisole (4-Methoxytoluene) 是食品调味剂,存在于依兰香油中。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Esther F A Brandon, et al. Implementation of Toxicokinetics in Toxicity studies--Toxicokinetics of 4-methylanisole and Its Metabolites in Juvenile and Adult Rats. Regul Toxicol Pharmacol. 2015 Oct;73(1):55-64.

4-甲基苯甲醚(MSO)物理化学性质

[ 密度 ]:
0.96

[ 沸点 ]:
174 ºC

[ 熔点 ]:
-32°C

[ 分子式 ]:
C₈H₁₀O

[ 分子量 ]:
122.164

[ 闪点 ]:
53 ºC

[ 精确质量 ]:
122.073166

[ PSA ]:
9.23000

[ LogP ]:
2.59

[ 外观性状 ]:
透明至略黄色液体

[ 蒸汽压 ]:
1.7±0.3 mmHg at 25°C

[ 折射率 ]:
1.494

[ 储存条件 ]:
库房通风低温干燥

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents. Combustible.

[ 水溶解性 ]:
slightly soluble

4-甲基苯甲醚(MSO)MSDS

4-甲基苯甲醚(MSO)毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BZ8780000

CHEMICAL NAME :: Anisole, p-methyl-

CAS REGISTRY NUMBER :: 104-93-8

LAST UPDATED :: 199701

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C8-H10-O

MOLECULAR WEIGHT :: 122.18

WISWESSER LINE NOTATION :: 1OR D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 12,393,1974 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1920 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 12,393,1974

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 6,214,1954

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 12,393,1974 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3360 mg/kg/4W-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood - other changes

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 12,393,1974 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 10 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83207 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 207 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83207 No. of Facilities: 1443 (estimated) No. of Industries: 8 No. of Occupations: 10 No. of Employees: 13288 (estimated) No. of Female Employees: 9258 (estimated)

4-甲基苯甲醚(MSO)安全信息

[ 符号 ]:

GHS02, GHS07, GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H226-H302-H315-H361-H412

[ 警示性声明 ]:
P273-P281

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R10;R22

[ 安全声明 (欧洲) ]:
S36/37-S16

[ 危险品运输编码 ]:
UN 1993 3/PG 3

[ WGK德国 ]:
1

[ RTECS号 ]:
BZ8780000

[ 包装等级 ]:
III

[ 危险类别 ]:
3

[ 海关编码 ]:
29093090

4-甲基苯甲醚(MSO)合成路线

4-甲基苯甲醚(MSO)上下游产品

4-甲基苯甲醚(MSO)上游产品

4-甲基苯甲醚(MSO)下游产品

4-甲基苯甲醚(MSO)制备

由对甲苯酚在氢氧化钠存在下与硫酸二甲酯经甲基化反应制得。反应后经中和洗涤，分层分离；减压蒸馏而得成品，工艺过程与2-甲基苯甲醚相仿。

4-甲基苯甲醚(MSO)海关

[ 海关编码 ]: 2909309090

[ 中文概述 ]:
2909309090 其他芳香醚及其卤化衍生物、磺化、硝化衍生物（包括亚硝化衍生物）。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2909309090 other aromatic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

4-甲基苯甲醚(MSO)文献

Identification of odorants in frankincense (Boswellia sacra Flueck.) by aroma extract dilution analysis and two-dimensional gas chromatography-mass spectrometry/olfactometry.

Phytochemistry 109 , 66-75, (2014)

Frankincense has been known, traded and used throughout the ages for its exceptional aroma properties, and is still commonly used in both secular and religious settings to convey a pleasant odor. Surp...

Developmental immunotoxicity testing of 4-methyl anisole.

Regul Toxicol Pharmacol 72 , 379-85, (2015)

The developmental immunotoxicity of 4-methyl anisole (4MA) was investigated in the rat. Four study designs were used, with either premating or post-weaning onset of exposure, continued to postnatal da...

Individual solvent/solute interactions through social isomerism.

J. Am. Chem. Soc. 125(46) , 13981-3, (2003)

Reversible coencapsulation of a solute molecule and a single solvent molecule takes place in solution at ambient temperature. Two isomeric complexes are formed (social isomers), and their relative ene...

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