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4.4'-次甲基-双(2-氯苯胺)

4.4'-次甲基-双(2-氯苯胺)用途

【用途一】
用作浇注型聚氨酯橡胶的硫化剂，也可用于固化环氧树脂

4.4'-次甲基-双(2-氯苯胺)名称

[ CAS 号 ]:
101-14-4

[ 中文名 ]:
4,4'-二氨基-3,3'-二氯二苯甲烷

[ 英文名 ]:
4,4'-methylene-bis-(2-chloroaniline)

[中文别名 ]:

3,3’-二氯-4,4’-二氨基二苯基甲烷

[英文别名 ]:

bisamine
Di-(4-amino-3-chlorophenyl)methane
curalinm
4,4'-Methylene bis(2-chloroaniline)
Aniline, 4,4'-methylenebis[2-chloro-
MOCA
MBOCA
4,4'-Methylene bis(o-chloroaniline)
Cyanaset
MFCD00047829

4.4'-次甲基-双(2-氯苯胺)物理化学性质

[ 密度 ]:
1.44

[ 沸点 ]:
412.0±40.0 °C at 760 mmHg

[ 熔点 ]:
102-107 °C(lit.)

[ 分子式 ]:
C₁₃H₁₂Cl₂N₂

[ 分子量 ]:
267.154

[ 闪点 ]:
203.0±27.3 °C

[ 精确质量 ]:
266.037750

[ PSA ]:
52.04000

[ LogP ]:
3.59

[ 外观性状 ]:
灰白色粉末带有淡气味

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.671

[ 储存条件 ]:
室温

[ 稳定性 ]:
Stable, but decomposes exothermically, and possibly explosively, above 200 C. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
<0.1 g/100 mL at 25 ºC

4.4'-次甲基-双(2-氯苯胺)MSDS

4.4'-次甲基-双(2-氯苯胺)毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CY1050000

CHEMICAL NAME :: Benzenamine, 4,4'-methylenebis(2-chloro-

CAS REGISTRY NUMBER :: 101-14-4

BEILSTEIN REFERENCE NO. :: 1882318

LAST UPDATED :: 199712

DATA ITEMS CITED :: 74

MOLECULAR FORMULA :: C13-H12-Cl2-N2

MOLECULAR WEIGHT :: 267.17

WISWESSER LINE NOTATION :: ZR CG D1R DZ CG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1140 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - ataxia Lungs, Thorax, or Respiration - cyanosis

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Lungs, Thorax, or Respiration - cyanosis Kidney, Ureter, Bladder - urine volume increased

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 640 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - ataxia Lungs, Thorax, or Respiration - cyanosis

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 64 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - ataxia Lungs, Thorax, or Respiration - cyanosis

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4050 mg/kg/77W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 25 gm/kg/89W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 27 gm/kg/79W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 27 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 11 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Skin and Appendages - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8100 mg/kg/77W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Endocrine - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 16 gm/kg/77W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Skin and Appendages - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 27 gm/kg/65W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Skin and Appendages - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 34 gm/kg/80W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 21 gm/kg/60W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Skin and Appendages - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 24 gm/kg/57W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors

TYPE OF TEST :: Specific locus test

TYPE OF TEST :: Micronucleus test

MUTATION DATA

TYPE OF TEST :: Unscheduled DNA synthesis

TEST SYSTEM :: Rodent - rabbit Liver

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 43,3120,1983 *** REVIEWS *** ACGIH TLV-Suspected human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 0.11 mg/m3 (0.01 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 4,65,1974 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 57,271,1993 IARC Cancer Review:Human Inadequate Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,246,1987 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 57,271,1993 IARC Cancer Review:Group 2A IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 57,271,1993 TOXICOLOGY REVIEW AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 39,496,1978 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.02 ppm (0.22 mg/m3);Skin;Carcinogen JAN 1993 OEL-BELGIUM:TWA 0.02 ppm (0.22 mg/m3);Skin;Carcinogen JAN 1993 OEL-FINLAND:TWA 0.02 ppm (0.2 mg/m3);STEL 0.06 ppm;Skin JAN 1993 OEL-FINLAND:TWA 0.02 ppm (0.2 mg/m3);STEL 0.06 ppm;Carcinogen JAN 1993 OEL-FRANCE:TWA 0.02 ppm (0.22 mg/m3);Carcinogen JAN 1993 OEL-GERMANY;Carcinogen JAN 1993 OEL-THE NETHERLANDS:TWA 0.02 ppm;Skin JAN 1993 OEL-SWEDEN;Carcinogen JAN 1993 OEL-SWITZERLAND:TWA 0.02 ppm (0.2 mg/m3);Skin JAN 1993 OEL-SWITZERLAND:TWA 0.02 ppm (0.22 mg/m3);Carcinogen JAN 1993 OEL-UNITED KINGDOM:TWA 0.005 mg/m3;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO MOCA-air:10H CA TWA 0.003 mg/m3 (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83341 No. of Facilities: 376 (estimated) No. of Industries: 15 No. of Occupations: 13 No. of Employees: 2094 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83341 No. of Facilities: 4 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 114 (estimated)

4.4'-次甲基-双(2-氯苯胺)安全信息

[ 符号 ]:

GHS07, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H341-H350-H410

[ 警示性声明 ]:
P201-P273-P281-P308 + P313-P501

[ 个人防护装备 ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T;N

[ 风险声明 (欧洲) ]:
R22;R45;R50-53

[ 安全声明 (欧洲) ]:
S53-S45-S60-S61

[ 危险品运输编码 ]:
UN 3077 9/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
CY1050000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2921590031

4.4'-次甲基-双(2-氯苯胺)合成路线

4.4'-次甲基-双(2-氯苯胺)上下游产品

4.4'-次甲基-双(2-氯苯胺)上游产品

4.4'-次甲基-双(2-氯苯胺)下游产品

4.4'-次甲基-双(2-氯苯胺)制备

1.由邻氯苯胺与盐酸反应生成邻氯苯胺盐酸盐后滴加甲醛进行缩合而制得粗品，粗品用液碱中和后经蒸汽蒸馏、水洗、在稀乙醇中重结晶、脱水、干燥而得成品。

2.由邻氯苯胺和甲醛缩合而成

缩合产物中除了上述反应生成的4,4'-对位二胺外，还有少量一元胺和三元胺等，其质量分数一般在10%上下。实际上MOCA的初始熔点和熔点范围大小就反映了MOCA纯度的高低。MOCA的生产工艺过程如下：

4.4'-次甲基-双(2-氯苯胺)海关

[ 海关编码 ]: 2921590031

[ 中文概述 ]:
2921590031 4,4’-二氨基-3,3’-二氯二苯基甲烷。监管条件:X(有毒化学品环境管理放行通知单)。增值税率:17.0%。退税率:9.0%。最低关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: X.有毒化学品环境管理放行通知单

[ Summary ]:
2921590031 4,4'-methylenebis(2-chloroaniline)。supervision conditions:x(environment control release notice for poisonous chemicals)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:30.0%

4.4'-次甲基-双(2-氯苯胺)文献

[Resolution of overlapping mass spectra of azobiphenyl dyes by subwindow factor analysis technique].

Se Pu 19(2) , 184-7, (2001)

Subwindow factor analysis(SWFA) has been proven to be an effective data processing technique. In this paper, it is applied to the resolution of overlapping GC-MS peaks. A two-component sample of azobi...

New approaches to extraction techniques in determination of 4,4'-methylenebis(2-chloroaniline) in air and water solutions.

Talanta 93 , 117-21, (2012)

Extraction techniques for 4,4'-methylenebis(2-chloroaniline) (MOCA) in air samples and water solutions were developed and compared. Classic techniques for air sampling of MOCA were enhanced by incorpo...

Oxidative DNA damage estimated by plasma 8-hydroxydeoxyguanosine (8-OHdG): influence of 4, 4'-methylenebis (2-chloroaniline) exposure and smoking.

J. Occup. Health 49(5) , 389-98, (2007)

Oxidative DNA damage may play an important role in the human carcinogenic process. Recently, we reported a case of bladder cancer among 4, 4'-methylenebis (2-chloroaniline) (MBOCA)-exposed workers. By...

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