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4,4'-亚甲基双(异氰酸苯酯)

4,4'-亚甲基双(异氰酸苯酯)用途

【用途一】
用于生产聚氨酯弹性体，制造合成纤维、人造革、无溶剂涂料等

4,4'-亚甲基双(异氰酸苯酯)名称

[ CAS 号 ]:
101-68-8

[ 中文名 ]:
双(4-异氰酸酯基苯基)甲烷

[ 英文名 ]:
4,4'-Diphenylmethane diisocyanate

[中文别名 ]:

[英文别名 ]:

EINECS 202-966-0
4,4′-Methylenebis(phenyl isocyanate)
4,4'-Methylenediphenyl diisocyanate
4,4'-Methylenebis(phenyl isocyanate)
diphenylmethane-4,4'-diisocyanate
MFCD00036131
desmodur44
caradate30
MDI
hylenem50

4,4'-亚甲基双(异氰酸苯酯)物理化学性质

[ 密度 ]:
1.19

[ 沸点 ]:
392 ºC

[ 熔点 ]:
38-44 °C

[ 分子式 ]:
C₁₅H₁₀N₂O₂

[ 分子量 ]:
250.252

[ 闪点 ]:
196 ºC

[ 精确质量 ]:
250.074234

[ PSA ]:
58.86000

[ LogP ]:
4.93

[ 外观性状 ]:
白色至淡黄色片或晶体

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.588

[ 储存条件 ]:
库房通风低温干燥,与含水物品、醇类、胺类分开储运

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents. Reacts violently with alcohols.

[ 水溶解性 ]:
decomposes

[ 凝固点 ]:
37℃

4,4'-亚甲基双(异氰酸苯酯)MSDS

4,4'-亚甲基双(异氰酸苯酯)毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NQ9350000

CHEMICAL NAME :: Isocyanic acid, methylenedi-p-phenylene ester

CAS REGISTRY NUMBER :: 101-68-8

BEILSTEIN REFERENCE NO. :: 0797662

LAST UPDATED :: 199806

DATA ITEMS CITED :: 46

MOLECULAR FORMULA :: C15-H10-N2-O2

MOLECULAR WEIGHT :: 250.27

WISWESSER LINE NOTATION :: OCNR D1R DNCO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Human

DOSE/DURATION :: 130 ppb/30M

TOXIC EFFECTS :: Immunological Including Allergic - increased immune response Nutritional and Gross Metabolic - body temperature increase

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9200 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 178 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3 mg/m3/18H/90D-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Lungs, Thorax, or Respiration - other changes Blood - other changes

TYPE OF TEST :: DNA damage

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lymphocyte

REFERENCE :: TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 36,37,1987 *** REVIEWS *** ACGIH TLV-TWA 0.051 mg/m3 (0.005 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 19,303,1979 IARC Cancer Review:Animal No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 19,303,1979 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD:air-CL 0.02 ppm (0.2 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,170,1971 OSHA PEL (Gen Indu):CL 0.02 ppm (0.2 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):CL 0.02 ppm (0.2 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):CL 0.02 ppm (0.2 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):CL 0.02 ppm (0.2 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-BELGIUM:TWA 0.005 ppm (0.051 mg/m3);STEL 0.02 ppm JAN 1993 OEL-DENMARK:TWA 0.005 ppm (0.050 mg/m3) JAN 1993 OEL-FRANCE:TWA 0.01 ppm (0.1 mg/m3);STEL 0.02 ppm (0.2 mg/m3) JAN 1993 OEL-GERMANY:TWA 0.01 ppm (0.1 mg/m3) JAN 1993 OEL-HUNGARY:TWA 0.05 mg/m3;STEL 0.1 mg/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 0.02 ppm (0.2 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 0.02 ppm (0.2 mg/m3) JAN 1993 OEL-POLAND:TWA 0.05 mg/m3 JAN 1993 OEL-RUSSIA:STEL 0.5 mg/m3;Skin JAN 1993 OEL-SWEDEN:TWA 0.005 ppm (0.05 mg/m3);STEL 0.01 ppm (0.1 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 0.01 ppm (0.1 mg/m3);STEL 0.02 ppm JAN 1993 OEL-THAILAND:TWA 0.02 ppm (0.2 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 0.02 mg/m3;STEL 0.07 mg/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO MDI-air:10H TWA 0.005 ppm;CL 0.02 ppm/10M REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 27780 No. of Facilities: 2896 (estimated) No. of Industries: 41 No. of Occupations: 48 No. of Employees: 53321 (estimated) No. of Female Employees: 13421 (estimated)

4,4'-亚甲基双(异氰酸苯酯)安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H315-H317-H319-H332-H334-H335-H351-H373

[ 警示性声明 ]:
P261-P280-P284-P304 + P340 + P312-P305 + P351 + P338-P342 + P311

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R20;R36/37/38;R42/43

[ 安全声明 (欧洲) ]:
S23;S36/37;S45

[ 危险品运输编码 ]:
UN 2811

[ RTECS号 ]:
NQ9350000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1

[ 海关编码 ]:
29291090

4,4'-亚甲基双(异氰酸苯酯)合成路线

4,4'-亚甲基双(异氰酸苯酯)上下游产品

4,4'-亚甲基双(异氰酸苯酯)上游产品

4,4'-亚甲基双(异氰酸苯酯)下游产品

4,4'-亚甲基双(异氰酸苯酯)制备

1.（1）光气合成法由苯胺和甲醛缩合制备二氨基二苯甲烷再由4，4'-二氨基二苯甲烷与光气反应而得本品。光气化反应在溶剂中进行，反应过程产生氯化氢，被吸收为盐酸，反应得到的粗品经精馏精制即得成品， MDI的生产过程与甲苯二异氰酸酯（TDI）等产品有许多共同性。（2）非光气合成法在室温下，在1000ml盛有4，4'-二氨基二苯甲烷（29.7g,0.15ml)的二氯甲烷（300ml)溶液的三颈瓶上装有两只滴液漏斗，其中分别盛有二（三氯甲烷）碳酸酯（29.6g，0.1ml)的二氯甲烷（200ml) 溶液和N a OH（24g,06mol)的水溶液（200ml),慢慢地滴加二（三氯甲烷）碳酸酯的二氯甲烷和N aOH的水溶液到剧烈搅拌着的4，4'-二氨基二苯甲烷的二氯甲烷溶液中，反应体系微有发热。控制两只溶液漏斗中溶液的滴加速度，使整个反应过程中维持反应体系的PH值在11-12之间。将反应瓶浸没在冷水浴中，维持反应体系在室温左右，待溶液滴加完毕后，继续在室温下反应2h。反应结束后，在分液漏斗中将水层和二氯甲烷层分离，水层用2×20ml二氯甲烷萃取；合并有机层，用无水硫酸镁干燥后除去大部分溶剂，参与物在硅胶柱色谱上用二氯甲烷：轻石油醚（7：3）作淋洗剂进行分离，得到浅黄色产物28.45 g，产率87%，熔点40-42℃。 2.见1.5-萘二异氰酸酯的制备。

4,4'-亚甲基双(异氰酸苯酯)海关

[ 海关编码 ]: 2929109000

[ 中文概述 ]:
2929109000. 其他异氰酸酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2929109000. other isocyanates. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

4,4'-亚甲基双(异氰酸苯酯)文献

Role of dermal exposure in systemic intake of methylenediphenyl diisocyanate (MDI) among construction and boat building workers.

Toxicol. Lett. 232(3) , 595-600, (2015)

The causal relationship between inhalation exposure to methylenediphenyl diisocyanate (MDI) and the risk of occupational asthma is well known, but the role of dermal exposure and dermal uptake of MDI ...

Development of sandwich ELISAs for the detection of aromatic diisocyanate adducts

J. Immunol. Methods 397(1-2) , 66-70, (2013)

Diisocyanates (dNCOs) are highly reactive low molecular weight chemicals commonly used in the manufacturing industry. Occupational exposures to dNCOs have been shown to elicit allergic sensitization a...

Genetic variants in antioxidant genes are associated with diisocyanate-induced asthma.

Toxicol. Sci. 129(1) , 166-73, (2012)

Diisocyanates are a common cause of occupational asthma, but risk factors are not well defined. A case-control study was conducted to investigate whether genetic variants of antioxidant defense genes,...

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