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硝吡咯菌素

硝吡咯菌素用途

Pyrrolnitrin 是从吡咯假单胞菌中分离出来的一种抗生素 (antibiotic)。Pyrrolnitrin 对真菌、酵母和革兰氏阳性菌具有广泛的抗菌活性。

硝吡咯菌素名称

[ CAS 号 ]:
1018-71-9

[ 中文名 ]:
硝吡咯菌素

[ 英文名 ]:
Pyrrolnitrin

[中文别名 ]:

吡咯尼林

[英文别名 ]:

Pyrrolnitrine
Pyrrolnitrin
Pirrolnitrina
Pyroace
3-chloro-4-(3-chloro-2-nitrophenyl)-1H-pyrrole
Pyrrolnitrinum

硝吡咯菌素生物活性

[ 描述 ]:

Pyrrolnitrin 是从吡咯假单胞菌中分离出来的一种抗生素 (antibiotic)。Pyrrolnitrin 对真菌、酵母和革兰氏阳性菌具有广泛的抗菌活性。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 真菌

信号通路 >> 抗感染 >> 细菌

[ 靶点 ]

Target: fungi, yeast and gram-positive bacteria[1]

[体外研究]

吡咯烷腈(0-100μg/ml)对不同MIC值的细菌和真菌具有抗菌活性。对金黄色葡萄球菌、分枝杆菌、枯草芽孢杆菌、白色念珠菌、黑曲霉、红色毛癣菌的MIC值分别为50μg/ml、100μg/ml、0.78μg/ml、10μg/ml、12.5μg/ml和1μg/ml[1]。吡咯烷腈(0-100μg/ml)在微量滴定板法中具有抗菌作用。它对氧化节杆菌ATCC 14358、凝固酶芽孢杆菌ATCC 7050、地衣芽孢杆菌ATCC 14580、枯草芽孢杆菌ATCC 6051和苏云金杆菌ATCC 10792的MIC为6.25μg/ml[2]。

[参考文献]

[1]. K H van Pée, et al. Biosynthesis of Pyrrolnitrin and Other Phenylpyrrole Derivatives by Bacteria. Nat Prod Rep. 2000 Apr;17(2):157-64.

[2]. N el-Banna, et al. Pyrrolnitrin From Burkholderia Cepacia: Antibiotic Activity Against Fungi and Novel Activities Against Streptomycetes.J Appl Microbiol. 1998 Jul;85(1):69-78.

[3]. R S Gordee, et al.Systemic Antifungal Activity of Pyrrolnitrin.Appl Microbiol. 1969 May;17(5):690-4.

硝吡咯菌素物理化学性质

[ 密度 ]:
1.523g/cm3

[ 沸点 ]:
410.5ºC at 760mmHg

[ 分子式 ]:
C₁₀H₆Cl₂N₂O₂

[ 分子量 ]:
257.07300

[ 闪点 ]:
202.1ºC

[ 精确质量 ]:
255.98100

[ PSA ]:
61.61000

[ LogP ]:
4.41990

[ 蒸汽压 ]:
1.42E-06mmHg at 25°C

[ 折射率 ]:
1.65

[ 储存条件 ]:
库房低温通风干燥

硝吡咯菌素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UX9450000

CHEMICAL NAME :: Pyrrole, 3-chloro-4-(3-chloro-2-nitrophenyl)-

CAS REGISTRY NUMBER :: 1018-71-9

BEILSTEIN REFERENCE NO. :: 1287646

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C10-H6-Cl2-N2-O2

MOLECULAR WEIGHT :: 257.08

WISWESSER LINE NOTATION :: T5MJ CG DR CG BNW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - relaxation (isolated tissue)

REFERENCE :: JAJAAA Journal of Antibiotics, Series A. (Tokyo, Japan) V.6-20, 1953-67. For publisher information, see JANTAJ. Volume(issue)/page/year: 18,211,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 68 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - relaxation (isolated tissue)

REFERENCE :: JAJAAA Journal of Antibiotics, Series A. (Tokyo, Japan) V.6-20, 1953-67. For publisher information, see JANTAJ. Volume(issue)/page/year: 18,211,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAJAAA Journal of Antibiotics, Series A. (Tokyo, Japan) V.6-20, 1953-67. For publisher information, see JANTAJ. Volume(issue)/page/year: 18,211,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - relaxation (isolated tissue)

REFERENCE :: JAJAAA Journal of Antibiotics, Series A. (Tokyo, Japan) V.6-20, 1953-67. For publisher information, see JANTAJ. Volume(issue)/page/year: 18,211,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 86 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - relaxation (isolated tissue)

REFERENCE :: JAJAAA Journal of Antibiotics, Series A. (Tokyo, Japan) V.6-20, 1953-67. For publisher information, see JANTAJ. Volume(issue)/page/year: 18,211,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 5,44,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 105 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - relaxation (isolated tissue)

REFERENCE :: JAJAAA Journal of Antibiotics, Series A. (Tokyo, Japan) V.6-20, 1953-67. For publisher information, see JANTAJ. Volume(issue)/page/year: 18,211,1965

硝吡咯菌素安全信息

[ 海关编码 ]:
2933990090

硝吡咯菌素合成路线

详细合成路线

硝吡咯菌素海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%