<生产厂家价格>

四羟丙基乙二胺

四羟丙基乙二胺用途

Quadrol 是一种免疫刺激剂,已被认为是加速伤口愈合的潜在有用药物。

四羟丙基乙二胺名称

[ CAS 号 ]:
102-60-3

[ 中文名 ]:
N,N,N',N'-四-(2羟基丙基)乙二胺

[ 英文名 ]:
Edetol

[中文别名 ]:

[英文别名 ]:

Edetol
1,1',1'',1'''-(Ethylenedinitrilo)-tetra-2-propanol
N,N,N',N'-Tetrakis(2-hydroxypropyl)ethylenediamine
Quadrol
N,N,N’N’-tetra(2-hydropropyl)ethylene diamine
THPE
1,1',1'',1'''-(ethylenedinitrilo)tetra-2-propanol
Entprol
EINECS 203-041-4
MFCD00004534

四羟丙基乙二胺生物活性

[ 描述 ]:

Quadrol 是一种免疫刺激剂,已被认为是加速伤口愈合的潜在有用药物。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[体外研究]

结果显示,用浓度为0.5mM,1mM和4mM的Quadrol孵育的巨噬细胞的活力与对照相同。然而,在16mM至32mM的浓度下,活力降低至对照的50％。 4小时后,浓度为1mM和4mM时,与28％的对照相比,Quadrol分别产生88％和80％的增强扩散。浓度为16mM的Quadrol在4小时后显示出巨噬细胞扩散的百分比降低。巨噬细胞暴露于1.0mM或4.0mM Quadrol浓度分别比暴露于单独培养基的细胞(34％)增加了吞噬活性,分别为41％和57％[1]。

[体内研究]

在植入后第8天,注射Quadrol的正常小鼠的植入物中的胶原蛋白量超过对照超过200％(p <0.025)。到第11天,胶原蛋白含量比对照增加超过300％(p <0.01),并且在创伤后两周结束时,正常和完全伤口愈合通常需要的时间间隔,胶原蛋白在植入物中累积。 Quadrol处理的小鼠比对照高约50％(p <0.1)。在第8天至第11天,Quadrol处理的STZ-糖尿病小鼠的植入物中胶原蛋白的累积比未处理的糖尿病对照高约100％。到第14天,胶原沉积比对照增加至200％(p <0.05)[ 2]。

[细胞实验]

进行标准台盼蓝排除试验以测量细胞活力（10）。将细胞暴露于增加浓度的Quadrol（0.5mM至32mM）并在用台盼蓝处理之前在37℃温育不同的时间长度[1]。

[动物实验]

在聚四氟乙烯（PTFE）管植入时，每个采样时间由5到7只动物组成的六个测试组（3个链脲佐菌素诱导的（STZ）糖尿病和3个非糖尿病）接受稀释剂（对照组）或Quadrol（10mM））从植入部位注射约1cm。在2至14天后从小鼠中回收的PTFE植入物冷冻储存直至处理，然后通过HPLC方法分析[2]。

[参考文献]

[1]. Bhide MV, et al. In vitro stimulation of macrophages by quadrol [N,N,N',N'-tetrakis(2-hydroxypropyl)ethylenediamine]. J Immunopharmacol. 1985;7(3):303-12.

[2]. Bhide MV, et al. Promotion of wound collagen formation in normal and diabetic mice by quadrol. Immunopharmacol Immunotoxicol. 1988;10(4):513-22.

[相关活性小分子]

四羟丙基乙二胺物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
369.1±0.0 °C at 760 mmHg

[ 熔点 ]:
32°C

[ 分子式 ]:
C₁₄H₃₂N₂O₄

[ 分子量 ]:
292.415

[ 闪点 ]:
145.7±17.4 °C

[ 精确质量 ]:
292.236206

[ PSA ]:
87.40000

[ LogP ]:
0.13

[ 外观性状 ]:
透明无色-淡黄色

[ 蒸汽压 ]:
0.0±1.8 mmHg at 25°C

[ 折射率 ]:
1.517

[ 储存条件 ]:
室温

[ 水溶解性 ]:
miscible

四羟丙基乙二胺MSDS

详细MSDS(安全技术说明书)

四羟丙基乙二胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UB5604000

CHEMICAL NAME :: 2-Propanol, 1,1',1'',1'''-(ethylenedinitrilo)tetra-

CAS REGISTRY NUMBER :: 102-60-3

BEILSTEIN REFERENCE NO. :: 1781143

LAST UPDATED :: 199709

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C14-H32-N2-O4

MOLECULAR WEIGHT :: 292.48

WISWESSER LINE NOTATION :: QY1&1N1YQ1&2N1YQ1&1YQ1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DABBBA Dissertation Abstracts International, B: The Sciences and Engineering. (University Microfilms International, 300 N. Zeeb Rd., Ann Arbor, MI 48106) V.30- 1969- Volume(issue)/page/year: 52,762,1991

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DABBBA Dissertation Abstracts International, B: The Sciences and Engineering. (University Microfilms International, 300 N. Zeeb Rd., Ann Arbor, MI 48106) V.30- 1969- Volume(issue)/page/year: 52,762,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 3900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C258,1991 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1905 No. of Facilities: 152 (estimated) No. of Industries: 4 No. of Occupations: 6 No. of Employees: 3701 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1905 No. of Facilities: 141 (estimated) No. of Industries: 15 No. of Occupations: 16 No. of Employees: 3730 (estimated) No. of Female Employees: 1831 (estimated)

四羟丙基乙二胺安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R43

[ 安全声明 (欧洲) ]:
S36/37-S37-S24

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
UB5604000

[ 海关编码 ]:
29221980

四羟丙基乙二胺合成路线

详细合成路线

四羟丙基乙二胺上下游产品

四羟丙基乙二胺上游产品

四羟丙基乙二胺下游产品

四羟丙基乙二胺海关

[ 海关编码 ]: 2922199090

[ 中文概述 ]:
2922199090. 其他氨基醇及其醚，酯和它们的盐（但含一种以上含氧基的除外）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

四羟丙基乙二胺文献

Autoclavable highly cross-linked polyurethane networks in ophthalmology.

Biomaterials 14(14) , 1089-97, (1993)

Highly cross-linked aliphatic polyurethane networks have been prepared by the bulk step reaction of low molecular weight polyols and hexamethylenediisocyanate (HDI). These polyurethane networks are op...

Sorption of Cu(II) complexes with ligands tartrate, glycine and quadrol by chitosan.

J. Hazard. Mater. 171(1-3) , 133-9, (2009)

The sorption by chitosan in Cu(II) solutions containing tartrate, glycine (amino acetic acid) and quadrol (N,N,N',N'-tetrakis(2-hydroxypropyl)ethylenediamine) as ligands has been investigated. The deg...

The behavior of organic components in copper recovery from electroless plating bath effluents using 3D electrode systems.

J. Hazard. Mater. 112(3) , 261-7, (2004)

An electrochemical method was applied for the recovery of copper both from the spent solutions and from the rinse waters of electroless copper plating baths, containing copper sulfate, formaldehyde, q...

更多文献