PGLA

PGLA用途

PGLa 是一种抗菌肽,对革兰氏阳性菌和阴性菌均具有抑菌作用。

PGLA名称

[ CAS 号 ]:
102068-15-5

[ 中文名 ]:
PGLA

[ 英文名 ]:
PGLa

[英文别名 ]:

PGLa

PGLA生物活性

[ 描述 ]:

PGLa 是一种抗菌肽,对革兰氏阳性菌和阴性菌均具有抑菌作用。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

多肽产品

[ 靶点 ]

Anti-bacteria[1]

[体外研究]

已知PGLa对革兰氏阳性和革兰氏阴性细菌(大肠杆菌,铜绿假单胞菌,化脓性链球菌和金黄色葡萄球菌)均具有抑菌作用,两种细菌细胞之间没有太大的选择性。 PGLa合成为天然(野生型)肽和在2Met处具有正亮氨酸而不是甲硫氨酸的突变体(命名为PGLa(Nle))。

[参考文献]

[1]. Radchenko DS, et al. Does a methionine-to-norleucine substitution in PGLa influence peptide-membrane interactions? Biochim Biophys Acta. 2016 Sep;1858(9):2019-27.

[相关活性小分子]

PGLA物理化学性质

[ 分子式 ]:
C₈₈H₁₆₂N₂₆O₂₂S

[ 分子量 ]:
1968.45000

[ 精确质量 ]:
1967.21000

[ PSA ]:
800.72000

[ LogP ]:
4.65010

PGLAMSDS

详细MSDS(安全技术说明书)

PGLA安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

PGLA文献

Synergistic transmembrane insertion of the heterodimeric PGLa/magainin 2 complex studied by solid-state NMR.

Biochim. Biophys. Acta 1788 , 1667-1679, (2009)

The skin secretions of amphibians are a rich source of antimicrobial peptides. The two antimicrobial peptides PGLa and magainin 2, isolated from the African frog Xenopus laevis, have been shown to act...

Synergistic insertion of antimicrobial magainin-family peptides in membranes depends on the lipid spontaneous curvature.

Biophys. J. 104(6) , L9-11, (2013)

PGLa and magainin 2 (MAG2) are amphiphilic antimicrobial peptides from frog skin with known synergistic activity. The orientation of the two helices in membranes was studied using solid-state (15)N-NM...

Rapid-prototyped and salt-leached PLGA scaffolds condition cell morpho-functional behavior.

J. Biomed. Mater. Res. A 85(2) , 466-76, (2008)

Three dimensional scaffolds microfabricated using pressure-assisted microsyringe (PAM) with controlled geometry and porous membranes obtained using salt leaching were both tested with three different ...

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